Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

4,587 questions · 5,761 findings · 495 reviews

No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

Ranked among the 5,000 newest matching findings; add words or filters to narrow the search.

Clinical examination with risk-based recall vs Clinical examination with 6-month recall

Dental caries · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in dental caries: number of tooth surfaces with any caries (ICDAS 1-6) compared with clinical examination with 6-month recall (high certainty).

1 finding from 1 review

Clinical examination with risk-based recall vs Clinical examination with 24-month recall

Dental caries: prevalence of root caries · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in dental caries: prevalence of root caries compared with clinical examination with 24-month recall; GRADE not reported.

1 finding from 1 review

Clinical examination with 24-month recall vs Clinical examination with 6-month recall

Dental caries: prevalence of root caries · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with 24-month recall showed no clear difference in dental caries: prevalence of root caries compared with clinical examination with 6-month recall; GRADE not reported.

1 finding from 1 review

Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline)

Salivary buffering capacity · Patients with drooling (sialorrhea) due to neurological disease

Salivary buffering capacity did not decrease after BoNT; one of two quasi-experimental studies reported a significant increase (ungraded; no effect estimate reported).

1 finding from 1 review
  • Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomes
    Before vs after BoNT injection (2018 study: significant buffering increase at 1 month; 2017 study no change) · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care
    The quasi-experimental studies of Tiigimae-Saar found different results concerning the changes in buffering capacity. For the analysis carried out in 2017, no statistically significant change was observed. By contrast,…
    2 studies
    GRADE not reported

Clinical examination with 24-month recall vs Clinical examination with 12-month recall

Caries increment in permanent teeth · Regular-attending primary-care dental patients aged 3, 16 or 18 years at entry (aged up to 20; low caries risk)

It is very uncertain whether clinical examination with 24-month recall changes dental caries: DMFS increment (permanent teeth) compared with clinical examination with 12-month recall (very low certainty).

1 finding from 1 review

Clinical examination with risk-based recall vs Clinical examination with 24-month recall

Dental caries: prevalence of moderate to extensive caries (ICDAS 3-6) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in dental caries: prevalence of moderate to extensive caries (ICDAS 3-6) compared with clinical examination with 24-month recall (moderate certainty).

1 finding from 1 review

Clinical examination with risk-based recall vs Clinical examination with 24-month recall

Dental caries · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in dental caries: number of tooth surfaces with any caries (ICDAS 1-6) compared with clinical examination with 24-month recall (moderate certainty).

1 finding from 1 review

Clinical examination with risk-based recall vs Clinical examination with 24-month recall

Cost (patient perspective): total cost per patient (GBP) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall led to higher cost (patient perspective): total cost per patient (GBP) compared with clinical examination with 24-month recall; GRADE not reported.

1 finding from 1 review

Povidone iodine rinse vs Saline rinse or placebo

Adverse effects · Critically ill patients receiving mechanical ventilation in ICU
1 finding from 1 review

Electric toothbrush (self, carer or carer-assisted brushing) vs Manual toothbrush

Plaque · Children and adults with mixed levels of ID; setting home, residential, day care, school, mixed or not specified

Electric toothbrush (self, carer or carer-assisted brushing) showed no clear difference in plaque (medium term) compared with manual toothbrush (self, carer or carer-assisted brushing) (low certainty).

2 findings from 1 review

Electric toothbrush (self, carer or carer-assisted brushing) vs Manual toothbrush

Behaviour, attitude and self-efficacy (participant/carer preference) · Children and adults with mixed levels of ID; setting home, residential, day care, school, mixed or not specified
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Long term (>12 months)
    Comparison 2.8 (reported; not GRADE-rated). One NRS (Bratel 1991, 23 participants), self-efficacy at 16 months: 10/12 people with ID using the electric toothbrush reported a preference for it, finding it easier to use…
    1 study · 23 participants
    GRADE not reported

Electric toothbrush (self, carer or carer-assisted brushing) vs Manual toothbrush

Gingivitis · Children and adults with mixed levels of ID; setting home, residential, day care, school, mixed or not specified
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Short term (<6 weeks)
    Electric vs manual toothbrush. Assorted gingival indices scale 0-4, 2-4 weeks; 252 participants (4 RCTs); Low. Four studies showed no significant differences for gingival inflammation short term; data could not be…
    4 studies · 252 participants
    Low

Toothpaste with a plaque-disclosing agent vs Conventional toothpaste

Gingivitis · Children aged 7 to 13 years with Down syndrome (mild to moderate ID); setting residential
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Short term (<6 weeks)
    Toothpaste with a plaque-disclosing agent vs conventional toothpaste, children with Down syndrome. Ainamo & Bay Gingival Bleeding Index, mean 10 days; percent mean difference 18 (intervention) vs 8 (control), P<0.001…
    1 study · 40 participants
    Very low

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Temporomandibular disorders (TMD), TMJ arthritis/involvement and orofacial pain · Children and adolescents with juvenile idiopathic arthritis (JIA)

TMD and TMJ arthritis/involvement (and orofacial pain) were consistently reported more frequently in children/adolescents with JIA than in healthy peers, though several studies had small samples; no pooled estimate (ungraded).

1 finding from 1 review