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Evidence found and GRADE certainty

4,678 questions · 4,859 findings · 283 reviews

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No studies found 1,225 · 25.2%GRADE not reported 215 · 4.4%Very low 1,241 · 25.5%Low 1,210 · 24.9%Moderate 776 · 16%High 192 · 4%

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Overall response rate Duration of · people with advanced gastric cancer

Summary of findings: Molecular‐targeted therapy plus chemotherapy showed no clear difference in overall response rate Duration of compared with chemotherapy alone (low certainty).

1 finding from 1 review

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Adverse event (any) Duration of · people with advanced gastric cancer

Summary of findings: Molecular‐targeted therapy plus chemotherapy probably leads to higher adverse event (any) Duration of compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

Summary of findings: Molecular‐targeted therapy plus chemotherapy vs chemotherapy alone

Severe adverse event (grade ≥ 3 ) Duration of · people with advanced gastric cancer

Summary of findings: Molecular‐targeted therapy plus chemotherapy probably leads to higher severe adverse event (grade ≥ 3 ) Duration of compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

Summary of findings: Lipid‐based nutrient supplements (full dose) vs Blended foods (full dose)

Progression to SAM · children with MAM

Summary of findings: Lipid‐based nutrient supplements (full dose) showed no clear difference in progression to SAM compared with blended foods (full dose) (high certainty).

1 finding from 1 review

Summary of findings: Lipid‐based nutrient supplements (full dose) vs Blended foods (full dose)

Has died · children with MAM

Summary of findings: Lipid‐based nutrient supplements (full dose) showed no clear difference in died compared with blended foods (full dose) (moderate certainty).

1 finding from 1 review

Summary of findings: Lipid‐based nutrient supplements (full dose) vs Blended foods (full dose)

Defaulted · children with MAM

Summary of findings: Lipid‐based nutrient supplements (full dose) showed no clear difference in defaulted compared with blended foods (full dose) (moderate certainty).

1 finding from 1 review

Summary of findings: Lipid‐based nutrient supplements (full dose) vs Blended foods (full dose)

Vomiting · children with MAM

Summary of findings: Lipid‐based nutrient supplements (full dose) may leads to higher vomiting compared with blended foods (full dose) (low certainty).

1 finding from 1 review

Summary of findings: Lipid‐based nutrient supplements (full dose) vs Blended foods (full dose)

Recovered · children with MAM

Summary of findings: Lipid‐based nutrient supplements (full dose) probably leads to higher recovered compared with blended foods (full dose) (moderate certainty).

1 finding from 1 review

Summary of findings: Lipid‐based nutrient supplements (full dose) vs Blended foods (full dose)

Not recovered · children with MAM

Summary of findings: Lipid‐based nutrient supplements (full dose) leads to lower not recovered compared with blended foods (full dose) (high certainty).

1 finding from 1 review

Summary of findings table ‐ Quality and volume of gastric residual vs quality of gastric residual alone

Number of infants with feed interruption episodes (lasting ≥ 12 hours) · feed interruption while monitoring gastric residual

It is very uncertain whether summary of findings table ‐ Quality and volume of gastric residual changes number of infants with feed interruption episodes (lasting ≥ 12 hours) compared with quality of gastric residual alone (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Quality and volume of gastric residual vs quality of gastric residual alone

Risk of invasive Infection · feed interruption while monitoring gastric residual

Summary of findings table ‐ Quality and volume of gastric residual showed no clear difference in risk of invasive Infection compared with quality of gastric residual alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Quality and volume of gastric residual vs quality of gastric residual alone

Mortality before hospital discharge · feed interruption while monitoring gastric residual

Summary of findings table ‐ Quality and volume of gastric residual showed no clear difference in all‐cause mortality before hospital discharge compared with quality of gastric residual alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Quality and volume of gastric residual vs quality of gastric residual alone

Risk of necrotising enterocolitis stage ≥ 2 · feed interruption while monitoring gastric residual

Summary of findings table ‐ Quality and volume of gastric residual showed no clear difference in risk of necrotising enterocolitis stage ≥ 2 compared with quality of gastric residual alone (low certainty).

1 finding from 1 review

Fecal microbiota transplantation vs control

Resolution of rCDI · adults with recurrent Clostridioides difficile infection (rCDI)

Summary of findings table ‐ Fecal microbiota transplantation (FMT) probably leads to higher resolution of rCDI compared with control (moderate certainty).

1 finding from 1 review