Death or bronchopulmonary dysplasia at 36 weeks PMA · preterm infants with chronic lung disease
Systemic corticosteroids (dexamethasone or hydrocortisone) probably leads to lower mortality or BPD at 36 weeks' PMA compared with control (placebo or nothing) (moderate certainty).
1 finding from 1 review
Cerebral palsy · preterm infants with chronic lung disease
Systemic corticosteroids (dexamethasone or hydrocortisone) showed no clear difference in cerebral palsy ‐ at latest reported age compared with control (placebo or nothing) (high certainty).
1 finding from 1 review
Death or cerebral palsy · preterm infants with chronic lung disease
Systemic corticosteroids (dexamethasone or hydrocortisone) showed no clear difference in mortality or cerebral palsy ‐ at latest reported age compared with control (placebo or nothing) (high certainty).
1 finding from 1 review
Mortality Mortality at latest · preventing bronchopulmonary dysplasia in preterm infants
Early systemic postnatal corticosteroids showed no clear difference in mortality at latest reported age compared with placebo or no treatment (high certainty).
1 finding from 1 review
BPD (36 weeks' PMA) · preventing bronchopulmonary dysplasia in preterm infants
Early systemic postnatal corticosteroids probably leads to lower BPD (36 weeks' PMA) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Death or bronchopulmonary dysplasia at 36 weeks PMA · preventing bronchopulmonary dysplasia in preterm infants
Early systemic postnatal corticosteroids leads to lower mortality or BPD at 36 weeks' PMA compared with placebo or no treatment (high certainty).
1 finding from 1 review
Gastrointestinal perforation during primary hospitalisation · preventing bronchopulmonary dysplasia in preterm infants
Early systemic postnatal corticosteroids leads to higher gastrointestinal perforation during primary hospitalisation compared with placebo or no treatment (high certainty).
1 finding from 1 review
Cerebral palsy · preventing bronchopulmonary dysplasia in preterm infants
Early systemic postnatal corticosteroids leads to higher cerebral palsy at latest reported age compared with placebo or no treatment (high certainty).
1 finding from 1 review
Death or cerebral palsy · preventing bronchopulmonary dysplasia in preterm infants
Early systemic postnatal corticosteroids showed no clear difference in mortality or cerebral palsy at latest reported age compared with placebo or no treatment (high certainty).
1 finding from 1 review
Epworth Sleepiness Scale (ESS), week 3№ of participants: 101(2 RCTs) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
High
Total nocturnal sleep time (minutes) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Difficulty waking in the morning, average of weeks 1 and 2№ of participants: 10(1 RCT) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Psychomotor vigilance task (PVT) reciprocal of reaction time, change from baseline№ of participants: 10(1 RCT) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Quality of life Functional Outcomes of Sleep Questionnaire · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Number of participants with any adverse events№ of participants: 10(1 RCT) · idiopathic hypersomnia
Clarithromycin showed no clear difference in number of participants with any adverse events№ of participants:… compared with placebo (low certainty).
1 finding from 1 review
OR 0.41 [0.01, 12.64]
Studies not reported
Low
Number of naps/week, week 3№ of participants: 99(2 RCTs) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Clinical Global Impression ‐ Severity (CGI‐S), change from baseline№ of participants: 30(1 RCT) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Clinical Global Impression ‐ Change (CGI‐C), proportion much improved or very much improved at week 3 № of participants: 70 (1 RCT) · idiopathic hypersomnia
Modafinil probably leads to higher clinical Global Impression ‐ Change (CGI‐C), proportion much… compared with placebo (moderate certainty).
1 finding from 1 review
OR 5.14 [1.76, 15]
Studies not reported
Moderate
improvement in the maintenance of wakefulness test · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
High
Effectiveness · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate