Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Donepezil 10 mg/day vs placebo

Serious adverse events (excluding death) at 24 weeks · vascular dementia and other vascular cognitive impairments

Donepezil 10 mg showed no clear difference in serious adverse events (excluding death) at 24 weeks compared with placebo (moderate certainty).

1 finding from 1 review

Rivastigmine vs placebo

Adverse events (all adverse events) at 24 to 26 weeks · vascular dementia and other vascular cognitive impairments

It is very uncertain whether rivastigmine changes adverse events (all adverse events) at 24 to 26 weeks compared with placebo (very low certainty).

1 finding from 1 review

Rivastigmine vs placebo

Serious adverse events (excluding death) at 24 to 26 weeks · vascular dementia and other vascular cognitive impairments

Rivastigmine showed no clear difference in serious adverse events (excluding death) at 24 to 26 weeks compared with placebo (low certainty).

1 finding from 1 review

Galantamine vs placebo

Clinical global impression: CIBIC‐Plus (Improvement) at 24 weeks 7‐point Likert scale · vascular dementia and other vascular cognitive impairments

Galantamine leads to higher clinical global impression: CIBIC‐Plus (Improvement) at 26 weeks compared with placebo (high certainty).

1 finding from 1 review

Galantamine vs placebo

Serious adverse events (excluding deaths) at 26 weeks · vascular dementia and other vascular cognitive impairments

Galantamine showed no clear difference in serious adverse events (excluding deaths) at 26 weeks compared with placebo (moderate certainty).

1 finding from 1 review