What do systematic reviews say?

Antihistamines vs placebo

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 149 participants
  Very low

Antihistamines vs placebo

It is very uncertain whether antihistamines changes vomiting ‐ postoperative compared with placebo (very low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.48 [0.29, 0.81]
  3 studies · 333 participants
  Very low

Anticholinergic medication vs placebo

Anticholinergics may leads to lower nausea ‐ intraoperative compared with placebo (low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.67 [0.51, 0.87]
  4 studies · 453 participants
  Low
• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Anticholinergic medication vs placebo

It is very uncertain whether anticholinergics changes vomiting ‐ intraoperative compared with placebo (very low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.79 [0.4, 1.54]
  4 studies · 453 participants
  Very low

5‐HT3 antagonists vs placebo

It is very uncertain whether 5‐HT3 antagonists changes vomiting ‐ intraoperative compared with placebo (very low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.46 [0.29, 0.73]
  11 studies · 1414 participants
  Very low

Anticholinergic medication vs placebo

Anticholinergics may leads to lower vomiting ‐ postoperative compared with placebo (low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.55 [0.41, 0.74]
  1 study · 161 participants
  Low

Sedation vs placebo

Sedatives probably leads to lower nausea ‐ intraoperative compared with placebo (moderate certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.65 [0.51, 0.82]
  8 studies · 593 participants
  Moderate
• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.25 [0.09, 0.71]
  2 studies · 145 participants
  Very low

Sedation vs placebo

Sedatives probably leads to lower vomiting ‐ intraoperative compared with placebo (moderate certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.35 [0.24, 0.52]
  8 studies · 593 participants
  Moderate

Sedation vs placebo

Sedatives may leads to lower vomiting ‐ postoperative compared with placebo (low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.09 [0.03, 0.28]
  2 studies · 145 participants
  Low

Opioid antagonists vs placebo

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported
• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.75 [0.39, 1.45]
  1 study · 120 participants
  Low

Opioid antagonists vs placebo

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Opioid antagonists vs placebo

Opioid antagonists showed no clear difference in vomiting ‐ postoperative compared with placebo (low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 1.25 [0.35, 4.43]
  1 study · 120 participants
  Low

Acupuncture or acupressure vs placebo

It is very uncertain whether acupressure/acupuncture changes nausea ‐ intraoperative compared with placebo (very low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.55 [0.41, 0.74]
  9 studies · 1221 participants
  Very low
• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.46 [0.27, 0.75]
  7 studies · 1069 participants
  Very low

Acupuncture or acupressure vs placebo

Acupressure/acupuncture may leads to lower vomiting ‐ intraoperative compared with placebo (low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.52 [0.33, 0.8]
  9 studies · 1221 participants
  Low

Acupuncture or acupressure vs placebo

It is very uncertain whether acupressure/acupuncture changes vomiting ‐ postoperative compared with placebo (very low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.52 [0.34, 0.79]
  7 studies · 1069 participants
  Very low

Ginger vs placebo

It is very uncertain whether ginger changes nausea ‐ intraoperative compared with placebo (very low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.66 [0.36, 1.21]
  2 studies · 331 participants
  Very low
• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.63 [0.22, 1.77]
  1 study · 92 participants
  Very low

Ginger vs placebo

It is very uncertain whether ginger changes vomiting ‐ intraoperative compared with placebo (very low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.62 [0.38, 1]
  2 studies · 331 participants
  Very low

Ginger vs placebo

It is very uncertain whether ginger changes vomiting ‐ postoperative compared with placebo (very low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.2 [0.02, 1.65]
  1 study · 92 participants
  Very low

5‐HT3 antagonists vs placebo

5‐HT3 antagonists may leads to lower vomiting ‐ postoperative compared with placebo (low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.47 [0.31, 0.69]
  10 studies · 1450 participants
  Low

Dopamine antagonists vs placebo

It is very uncertain whether dopamine antagonists changes nausea ‐ intraoperative compared with placebo (very low certainty).

• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.38 [0.27, 0.52]
  15 studies · 1180 participants
  Very low
• Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section 2021 · Cochrane Headline outcomes only
  RR 0.61 [0.48, 0.79]
  7 studies · 601 participants
  Low