Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,696 questions · 3,815 findings · 855 reviews

No studies found 573 · 15%GRADE not reported 374 · 9.8%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Long protocol vs long protocol (extend GnRHa 12 days after HCG)

Live birth or ongoing pregnancy · women undergoing pituitary suppression in assisted reproduction

Long protocol (GnRHa until HCG) showed no clear difference in live birth and ongoing pregnancies per woman randomised compared with long protocol (extend GnRHa 12 days after HCG) (low certainty).

1 finding from 1 review

Long protocol vs long protocol (extend GnRHa 12 days after HCG)

Clinical pregnancy rate · women undergoing pituitary suppression in assisted reproduction

Long protocol (GnRHa until HCG) showed no clear difference in clinical pregnancies per woman randomised compared with long protocol (extend GnRHa 12 days after HCG) (low certainty).

1 finding from 1 review

Flutamide 250 mg once to b.i.d. vs metformin 1275 mg to 1700 mg per day

Proportion of participants who reported an adverse event · women with hirsutism

It is very uncertain whether flutamide 250 mg once to twice daily changes proportion of participants who reported an adverse event compared with metformin 1275 mg to 1700 mg per day (very low certainty).

1 finding from 1 review

Oral vs IV followed by oral (11 days) therapy

Renal parenchymal damage at 6 to 12 months: all included children with acute pyelonephritis DMSA scans · children with acute pyelonephritis

Oral showed no clear difference in renal parenchymal damage at 6 to 12 months: all included children… compared with IV followed by oral (11 days) therapy (moderate certainty).

1 finding from 1 review

Oral vs IV followed by oral (11 days) therapy

Renal parenchymal damage at 6 to 12 months: children with renal parenchymal damage on initial DMSA · children with acute pyelonephritis

Oral showed no clear difference in renal parenchymal damage at 6 to 12 months: children with renal… compared with IV followed by oral (11 days) therapy (moderate certainty).

1 finding from 1 review