Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,320 questions · 4,561 findings · 388 reviews

No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Resin infiltration vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care)

Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

Resin infiltration led to lower caries (lesion) progression (radiographic) compared with fluoride varnish, sham/placebo, or flossing advice (non-invasive…; GRADE not reported.

1 finding from 1 review

Initiation of water fluoridation (artificial or natural) vs Low/non-fluoridated water (0.4 ppm fluoride or less)

Caries in deciduous teeth (change in dmft) · People of all ages in a community setting; the included caries studies were all in children aged 3 to 16 years

Initiation of water fluoridation (artificial or natural) may leads to lower caries in deciduous teeth (change in dmft) compared with low/non-fluoridated water (0.4 ppm fluoride or less) (low certainty).

1 finding from 1 review

Initiation of water fluoridation (artificial or natural) vs Low/non-fluoridated water (0.4 ppm fluoride or less)

Caries increment in permanent teeth · Children aged about 12 to 16 years (Hardwick 1982), community setting

Initiation of water fluoridation (artificial or natural) led to lower caries in permanent teeth (change in DMFS) compared with low/non-fluoridated water (0.4 ppm fluoride or less); GRADE not reported.

1 finding from 1 review

Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

Material deficiency (retention/adaptation loss; re-treatment) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
1 finding from 1 review

Initiation of water fluoridation (artificial or natural) vs Low/non-fluoridated water (0.4 ppm fluoride or less)

Change in proportion of caries-free children (deciduous teeth) · People of all ages in a community setting; the included caries studies were all in children aged 3 to 16 years

Initiation of water fluoridation (artificial or natural) may leads to higher change in proportion of caries-free children (deciduous teeth) compared with low/non-fluoridated water (0.4 ppm fluoride or less) (low certainty).

1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Mandibular ramus growth · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Stability of anterior open bite correction (1 year after treatment) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Reduction or treatment of obstructive sleep apnoea syndrome (OSAS) or upper airway resistance syndrome (UARS) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Mandibular ramus growth · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (12 months)
    Cephalometric data (SNA, Co-A, SNB, Ar-Go, Ar.GoMe, Co-Gn, ANB) were reported to be not significantly different between groups; effects were dento-alveolar rather than skeletal. No pooled estimate (Almeida 2005).
    1 study
    GRADE not reported

Intraligamental injection local anaesthetic vs no treatment

Postoperative anxiety · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…
1 finding from 1 review

Infiltration injection LA and intraligamental injection LA (3-arm) vs no treatment

Postoperative pain or distress · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…
1 finding from 1 review

Intraligamental injection local anaesthetic vs no treatment

Lip or cheek biting, numbness or allergy · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…
1 finding from 1 review

Infiltration injection LA and intraligamental injection LA (3-arm) vs no treatment

Participant satisfaction · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…

The review found no eligible studies for this question.

1 finding from 1 review

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Alteration of hyperdivergent growth pattern · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (12 months)
    The angles (SN.GoGN, SN.PP, NS.Gn) and linear measures (AFA, AFP, AFAI) did not demonstrate significant alterations between groups; interventions did not produce significant changes in the skeletal maxillary or…
    1 study
    GRADE not reported

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Expansion of the upper and lower jaw · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (12 months)
    Listed among the outcome measures evaluated by Almeida 2005. No separate width/expansion estimate is reported in the text; the review concluded the interventions produced no significant change in the skeletal maxillary…
    1 study
    GRADE not reported

Infiltration injection LA and intraligamental injection LA (3-arm) vs no treatment

Intraoperative or postoperative bleeding · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…

The review found no eligible studies for this question.

1 finding from 1 review

Infiltration injection LA and intraligamental injection LA (3-arm) vs no treatment

Physiological parameters (cardiac/respiratory events; type and volume of GA drug) · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…

The review found no eligible studies for this question.

1 finding from 1 review

Primary outcome: topical local anaesthetics vs placebo or no treatment

Postoperative pain or distress · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…
1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Patient satisfaction · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Infiltration injection local anaesthetic vs no treatment or placebo

Lip or cheek biting · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…
1 finding from 1 review