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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,353 questions in 210 reviews · Neonatal
current versionsNo studies 432 · 18.4%Ungraded 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Morphine vs buprenorphine Treatment failure To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | RR 0.79 [0.36, 1.74] | 3 studies · 113 participants | Very low |
Morphine vs buprenorphine Seizures To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | RR 0.33 [0.01, 7.5] | 3 studies · 113 participants | Very low |
Morphine vs buprenorphine Neonatal or infant mortality · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Morphine vs buprenorphine Neurodevelopmental disability · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Morphine vs buprenorphine Days hospitalisation · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 3 studies · 113 participants | Moderate |
Opioid vs placebo or no treatment / usual care Seizures To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 80 participants | Very low |
Morphine vs buprenorphine Days treatment · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 3 studies · 112 participants | Moderate |
Morphine vs buprenorphine Adverse events (treatment‐related) To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | RR 0.33 [0.01, 7.5] | 3 studies · 113 participants | Very low |
Morphine vs dilute tincture of opium Treatment failure · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Morphine vs dilute tincture of opium Seizures · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Morphine vs dilute tincture of opium Neonatal or infant mortality · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Morphine vs dilute tincture of opium Neurodevelopmental disability · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Morphine vs dilute tincture of opium Days hospitalisation · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 33 participants | Low |
Morphine vs dilute tincture of opium Days treatment · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 33 participants | Low |
Morphine vs dilute tincture of opium Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs clonidine Treatment failure To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 31 participants | Low |
Opioid vs placebo or no treatment / usual care Neonatal or infant mortality · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs clonidine Seizures · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs clonidine Neonatal or infant mortality · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs clonidine Neurodevelopmental disability · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs clonidine Days hospitalisation · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 31 participants | Low |
Opioid vs clonidine Days treatment · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 31 participants | Low |
Opioid vs clonidine Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs diazepam Treatment failure To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | RR 0.43 [0.23, 0.8] | 2 studies · 86 participants | Low |
Opioid vs diazepam Seizures To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs diazepam Neonatal or infant mortality · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs diazepam Neurodevelopmental disability · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs placebo or no treatment / usual care Neurodevelopmental disability · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs diazepam Days hospitalisation · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 34 participants | Very low |
Opioid vs diazepam Days treatment · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 33 participants | Very low |
Opioid vs diazepam Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs phenobarbital Treatment failure To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | RR 0.51 [0.35, 0.74] | 6 studies · 458 participants | Moderate |
Opioid vs phenobarbital Seizures To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | RR 0.08 [0, 1.44] | 3 studies · 281 participants | Very low |
Opioid vs phenobarbital Neonatal or infant mortality · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs phenobarbital Neurodevelopmental disability · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs phenobarbital Days hospitalisation · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 3 studies · 166 participants | Low |
Opioid vs phenobarbital Days treatment · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 6 studies · 349 participants | Low |
Opioid vs phenobarbital Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 96 participants | Low |
Opioid vs placebo or no treatment / usual care Days hospitalisation · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 80 participants | Very low |
Opioid vs chlorpromazine Treatment failure To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | RR 0.08 [0.01, 0.62] | 1 study · 90 participants | Moderate |
Opioid vs chlorpromazine Seizures To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 90 participants | Low |
Opioid vs chlorpromazine Neonatal or infant mortality · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs chlorpromazine Neurodevelopmental disability · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs chlorpromazine Days hospitalisation · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid vs chlorpromazine Days treatment · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 76 participants | Low |
Opioid vs chlorpromazine Adverse events (treatment related) · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 90 participants | Low |
Opioid vs placebo or no treatment / usual care Days treatment · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | 1 study · 80 participants | Very low |
Opioid vs placebo or no treatment / usual care Adverse events (treatment‐related) To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |
Morphine vs methadone Treatment failure To discharge · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | RR 1.59 [0.95, 2.67] | 2 studies · 147 participants | Low |
Morphine vs methadone Seizures · newborn infants with opioid withdrawal Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane | no estimate extracted | NR | No studies |