Intervention not reported
RT60 (5 RCTs; 713 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
The intervention probably leads to lower RT60 (5 RCTs; 713 participants) (moderate certainty).
1 finding from 1 review
Intervention not reported
BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
The intervention showed no clear difference in BEV_RT (1 RCT; 75 participants); GRADE not reported.
1 finding from 1 review
Intervention not reported
RT40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
The intervention may leads to lower RT40 (4 RCTs; 930 participants) (low certainty).
1 finding from 1 review
Intervention not reported
TMZ (3 RCTs, 538 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
The intervention may leads to lower TMZ (3 RCTs, 538 participants) (low certainty).
1 finding from 1 review
Intervention not reported
CRT (2 RCTs; 635 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
The intervention led to lower CRT (2 RCTs; 635 participants); GRADE not reported.
1 finding from 1 review
Intervention not reported
BEV_CRT (1 RCT; 73 participants) · elderly people with newly diagnosed glioblastoma Interventions: radiotherapy with 40 Gy in 15 fractions (RT40); radiotherapy with 60 Gy in…
The intervention led to lower BEV_CRT (1 RCT; 73 participants); GRADE not reported.
1 finding from 1 review
Intervention not reported
RT 40 (4 RCTs; 930 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…
1 finding from 1 review
Intervention not reported
BEV_RT (1 RCT; 75 participants) · elderly people with newly diagnosed glioblastoma Interventions: chemoradiotherapy (CRT); chemoradiotherapy plus bevacizumab (BEV_CRT);…
The intervention showed no clear difference in BEV_RT (1 RCT; 75 participants) (low certainty).
1 finding from 1 review
Prostate cancer‐specific death5
It is very uncertain whether whole gland primary cryotherapy changes time to death from prostate cancer (absolute effects:… compared with external beam radiotherapy (EBRT) (very low certainty).
1 finding from 1 review
Quality of life ‐ urinary function
1 finding from 1 review
Quality of life ‐ bowel function
1 finding from 1 review
Quality of life ‐ sexual function
1 finding from 1 review
Major adverse events
It is very uncertain whether whole gland primary cryotherapy changes major adverse events compared with external beam radiotherapy (EBRT) (very low certainty).
1 finding from 1 review
Time to death from any cause (absolute effects: overall mortality)
It is very uncertain whether whole gland primary cryotherapy changes time to death from any cause (absolute effects: overall mortality) compared with external beam radiotherapy (EBRT) (very low certainty).
1 finding from 1 review
Secondary interventions for treatment failure ‐ not reported
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality at 1 year · people with advanced biliary tract carcinomas
It is very uncertain whether gemcitabine plus oxaliplatin changes all‐cause mortality at 1 year compared with 5‐fluorouracil plus cisplatin plus radiotherapy (very low certainty).
1 finding from 1 review
Serious adverse events · people with advanced biliary tract carcinomas
It is very uncertain whether gemcitabine plus oxaliplatin changes serious adverse events compared with 5‐fluorouracil plus cisplatin plus radiotherapy (very low certainty).
1 finding from 1 review
Health‐related quality of life · people with advanced biliary tract carcinomas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Overall response rate · people with advanced biliary tract carcinomas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Time to progression of the tumour · people with advanced biliary tract carcinomas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found