Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,097 questions · 1,119 findings · 70 reviews · Kidney and Transplant

No studies found 271 · 24.2%GRADE not reported 17 · 1.5%Very low 271 · 24.2%Low 349 · 31.2%Moderate 182 · 16.3%High 29 · 2.6%

Low vs higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes

Malignancy · primary immunosuppression in kidney transplant recipients

Low showed no clear difference in all malignancy compared with higher dose target of rapamycin inhibitor (TOR‐I): primary outcomes (moderate certainty).

1 finding from 1 review

Low vs higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes

Number needing to change treatment · primary immunosuppression in kidney transplant recipients

Low showed no clear difference in number needing to change treatment compared with higher dose target of rapamycin inhibitor (TOR‐I): primary outcomes (low certainty).

1 finding from 1 review

Low vs higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes

Diabetes · primary immunosuppression in kidney transplant recipients

Low probably leads to lower diabetes compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (moderate certainty).

1 finding from 1 review

Low vs higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes

Lymphoma/PTLD · primary immunosuppression in kidney transplant recipients

Low showed no clear difference in lymphoma/PTLD compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (moderate certainty).

1 finding from 1 review

Low vs higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes

Acne/rash · primary immunosuppression in kidney transplant recipients

Low showed no clear difference in acne/rash compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (low certainty).

1 finding from 1 review

Low vs higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes

Hypercholesterolaemia · primary immunosuppression in kidney transplant recipients

Low probably leads to lower hypercholesterolaemia compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (moderate certainty).

1 finding from 1 review

Target of rapamycin inhibitors (TOR‐I) vs calcineurin inhibitors (CNI): main outcomes

Wound complications · primary immunosuppression in kidney transplant recipients

Target of rapamycin inhibitors (TOR‐I) probably leads to higher adverse wound outcomes: all complications compared with calcineurin inhibitors (CNI): main outcomes (moderate certainty).

1 finding from 1 review

Low vs higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes

Anaemia · primary immunosuppression in kidney transplant recipients

Low may leads to lower anaemia compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (low certainty).

1 finding from 1 review

Low vs higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes

Thrombocytopenia · primary immunosuppression in kidney transplant recipients

Low may leads to lower thrombocytopenia compared with higher dose target of rapamycin inhibitor (TOR‐ I): secondary outcomes (low certainty).

1 finding from 1 review

Target of rapamycin inhibitors (TOR‐I) vs calcineurin inhibitors (CNI): main outcomes

All malignancies · primary immunosuppression in kidney transplant recipients

Target of rapamycin inhibitors (TOR‐I) showed no clear difference in all malignancies compared with calcineurin inhibitors (CNI): main outcomes (moderate certainty).

1 finding from 1 review

Target of rapamycin inhibitors (TOR‐I) vs calcineurin inhibitors (CNI): main outcomes

Number needing to change treatment · primary immunosuppression in kidney transplant recipients

Target of rapamycin inhibitors (TOR‐I) probably leads to higher number needing to change treatment compared with calcineurin inhibitors (CNI): main outcomes (moderate certainty).

1 finding from 1 review

Tenckhoff catheter with artificial curve at tunnel tract vs swan‐neck

Peritonitis · preventing catheter‐related infections in chronic peritoneal dialysis patients

Tenckhoff catheter with artificial curve at tunnel tract showed no clear difference in peritonitis compared with swan‐neck (low certainty).

2 findings from 1 review

Tenckhoff catheter with artificial curve at tunnel tract vs swan‐neck

Exit‐site/tunnel infection · preventing catheter‐related infections in chronic peritoneal dialysis patients

Tenckhoff catheter with artificial curve at tunnel tract showed no clear difference in exit‐site/tunnel infection compared with swan‐neck (moderate certainty).

2 findings from 1 review

Tenckhoff catheter with artificial curve at tunnel tract vs swan‐neck

Catheter removal or replacement · preventing catheter‐related infections in chronic peritoneal dialysis patients

Tenckhoff catheter with artificial curve at tunnel tract showed no clear difference in catheter removal or replacement compared with swan‐neck (moderate certainty).

1 finding from 1 review

Tenckhoff catheter with artificial curve at tunnel tract vs swan‐neck

Technique failure · preventing catheter‐related infections in chronic peritoneal dialysis patients

Tenckhoff catheter with artificial curve at tunnel tract showed no clear difference in technique failure compared with swan‐neck (moderate certainty).

1 finding from 1 review

Tenckhoff catheter with artificial curve at tunnel tract vs swan‐neck

Death (all causes) · preventing catheter‐related infections in chronic peritoneal dialysis patients

Tenckhoff catheter with artificial curve at tunnel tract showed no clear difference in death (all causes) compared with swan‐neck (low certainty).

1 finding from 1 review