Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

480 questions · 559 findings · 16 reviews · Endodontics and dental trauma

No studies found 75 · 13.4%GRADE not reported 394 · 70.5%Very low 39 · 7%Low 36 · 6.4%Moderate 14 · 2.5%High 1 · 0.2%

Biodentine vs Propolis

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Biodentine showed no clear difference in clinical failure compared with propolis; GRADE not reported.

1 finding from 1 review

Vitapex (calcium hydroxide/iodoform) vs Sealapex (eugenol-free calcium hydroxide)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Vitapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with sealapex (eugenol-free calcium hydroxide); GRADE not reported.

1 finding from 1 review

Non-rinse conditioner + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether non-rinse conditioner + acetone-based total-etch adhesive changes radiological failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Glycerrhetinic acid/antibiotic mixture vs Calcium hydroxide (CH)

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported

Potassium nitrate/dimethyl isosorbide/polycarboxylate cement (KNO3/DMI/PCa) vs Potassium nitrate/polycarboxylate cement (KNO3/PCa)

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Hodosh 2003 (Analysis 3.1): all 18 patients receiving KNO3/DMI/PCa responded favourably (0/18 developed clinical symptoms) versus 9/17 in the KNO3/PCa group; symptomatic teeth required endodontic therapy or extraction.…
    1 study · 35 participants
    GRADE not reported

Calcium hydroxide cement (Dycal) vs Zinc oxide and eugenol (ZOE)

Clinical symptoms at 12 months · Adults (aged 20 to 60 years, mean 27) with deep carious lesions in permanent teeth (indirect or direct pulp capping, or complete caries…
1 finding from 1 review
  • Pulp management for caries in adults: maintaining pulp vitality 2007 · Cochrane All outcomes
    12 months · Complete caries removal
    Analysis 2.2 (clinical symptoms at 12 months following complete caries removal, Dycal vs Cavitec). Fitzgerald 1991: 151 teeth in 55 patients (analysis at tooth level, not patient level); substantial attrition (11 teeth…
    1 study · 151 participants
    GRADE not reported

Calcium hydroxide (CH) vs Zinc oxide and eugenol (ZOE)

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported

Life (calcium hydroxide pulp-capping material) vs Zinc oxide and eugenol (ZOE)

Clinical symptoms at 12 months · Adults (aged 20 to 60 years, mean 27) with deep carious lesions in permanent teeth (indirect or direct pulp capping, or complete caries…
1 finding from 1 review
  • Pulp management for caries in adults: maintaining pulp vitality 2007 · Cochrane All outcomes
    12 months · Complete caries removal
    Analysis 2.2 (clinical symptoms at 12 months following complete caries removal, Life vs Cavitec). Fitzgerald 1991: 151 teeth in 55 patients (analysis at tooth level, not patient level); substantial attrition (11 teeth…
    1 study · 151 participants
    GRADE not reported

Potassium nitrate/dimethyl isosorbide/polycarboxylate cement (KNO3/DMI/PCa) vs Polycarboxylate cement (PCa) alone

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Hodosh 2003 (Analysis 3.1): all 18 patients receiving KNO3/DMI/PCa responded favourably (0/18 developed clinical symptoms) versus 10/12 in the PCa group. "The results in groups two and three were statistically…
    1 study · 30 participants
    GRADE not reported

Glycerrhetinic acid/antibiotic mixture vs Zinc oxide and eugenol (ZOE)

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported

Potassium nitrate/polycarboxylate cement (KNO3/PCa) vs Polycarboxylate cement (PCa) alone

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Hodosh 2003 (Analysis 3.1): 9/17 in the KNO3/PCa group and 10/12 in the PCa group developed clinical symptoms requiring endodontic therapy or extraction. No significance test reported for this specific contrast; no…
    1 study · 29 participants
    GRADE not reported

Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD

Mean change in health-related quality of life or participant-expressed satisfaction with the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Sodium hypochlorite 1%

Change in periapical radiolucency (radiography or CBCT), up to 1 year after treatment · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse

Proportion of participants with new or worsening signs/symptoms of inflammation requiring a revisit, up to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review