Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,410 questions · 8,901 findings · 1,091 reviews

No studies found 1,687 · 19%GRADE not reported 1,469 · 16.5%Very low 1,969 · 22.1%Low 2,060 · 23.1%Moderate 1,302 · 14.6%High 414 · 4.7%

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Taxane followed by anthracyclines vs anthracyclines followed by taxane

Adverse events: neurotoxicity (grade 3/4) ( · neoadjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in adverse events: neurotoxicity (grade 3/4) ( compared with anthracyclines followed by taxane (low certainty).

1 finding from 1 review

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Treatment adherence (defined as dose reduction) ( · neoadjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in treatment adherence (defined as dose reduction) ( compared with anthracyclines followed by taxane (moderate certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in death (before hospital discharge) or BPD(supplemental… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in BPD (supplemental oxygen/respiratory support at 36 weeks'… compared with nasal intermittent positive pressure ventilation (low certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in treatment failure within 72 hours of trial entry compared with nasal intermittent positive pressure ventilation (moderate certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

Mechanical ventilation within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in mechanical ventilation within 72 hours of trial entry compared with nasal intermittent positive pressure ventilation (moderate certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

Nasal trauma (during assigned treatment) · preterm infants requiring primary respiratory support

Nasal high flow probably leads to lower nasal trauma (during assigned treatment) compared with nasal intermittent positive pressure ventilation (moderate certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in BPD (supplemental oxygen/respiratory support at 36 weeks'… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow probably leads to higher treatment failure within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Mechanical ventilation within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in mechanical ventilation within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

It is very uncertain whether nasal high flow changes death (before hospital discharge) or BPD (supplemental… compared with nasal intermittent positive pressure ventilation (very low certainty).

1 finding from 1 review

Partial pulpotomy with one-unit longer follow-up vs Partial pulpotomy with one-unit shorter follow-up

Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure

In the high-risk-study-excluded sensitivity meta-regression, longer follow-up was associated with lower success.

1 finding from 1 review