Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,017 questions · 1,061 findings · 131 reviews

No studies found 193 · 18.2%GRADE not reported 65 · 6.1%Very low 237 · 22.3%Low 325 · 30.6%Moderate 187 · 17.6%High 54 · 5.1%

Intravenous ceftazidime with tobramycin vs ciprofloxacin

Isolation of other micro‐organisms from the respiratory tract: number of participants isolating other micro‐organisms within the 15‐month · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Intravenous ceftazidime with tobramycin leads to higher isolation of other micro‐organisms from the respiratory tract:… compared with oral ciprofloxacin (high certainty).

1 finding from 1 review

Intravenous ceftazidime with tobramycin vs ciprofloxacin

Adverse effects of antibiotics · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Intravenous ceftazidime with tobramycin probably leads to lower adverse effects of antibiotics: compared with oral ciprofloxacin (moderate certainty).

1 finding from 1 review

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Pain after birth requiring analgesia (not prespecified) · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids probably leads to higher pain after birth requiring analgesia (not prespecified) compared with no uterotonic agents (moderate certainty).

1 finding from 1 review

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Maternal blood loss of 500 mL or greater · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids may leads to lower estimated or measured blood loss of at least 500 mL visual estimation compared with no uterotonic agents (low certainty).

1 finding from 1 review

Summary of findings ‐ Intravenous lorazepam vs intranasal lorazepam

Seizure cessation: within 10 minutes · Children with acute tonic‐clonic seizures

Summary of findings ‐ Intravenous lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intranasal lorazepam (moderate certainty).

1 finding from 1 review