Findings

What do systematic reviews say?

578 questions · 600 findings · 55 reviews · Headline outcomes only

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No studies found 143 · 23.8%GRADE not reported 69 · 11.5%Very low 100 · 16.7%Low 142 · 23.7%Moderate 116 · 19.3%High 30 · 5%

Pentoxifylline vs placebo

Side effects (number of cases or proportion) (4–52 weeks' · intermittent claudication

1 finding from 1 review

Pentoxifylline for intermittent claudication 2020 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1837 participants
Low

Supervised exercise therapy vs home exercises

Maximal treadmill walking distance after 3 months · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 351 participants
Moderate

Supervised exercise therapy vs walking advice

Self‐reported functional impairment after 3 months (Walking Impairment Questionnaire combined) Scale: 1 to 100 (higher scores indicate better walking) · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 483 participants
High

Home‐based exercise therapy vs walking advice

Maximal treadmill walking distance after 3 months · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 137 participants
Moderate

Home‐based exercise therapy vs walking advice

Pain‐free walking distance · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 107 participants
Low

Home‐based exercise therapy vs walking advice

Quality of Life: SF‐36 (physical component) · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Home‐based exercise therapy vs walking advice

Health‐related quality of life (mental) · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Home‐based exercise therapy vs walking advice

Self‐reported functional impairment after 3 months (Walking Impairment Questionnaire combined) Scale: 1 to 100 (higher scores indicate better walking) · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 79 participants
Moderate

Supervised exercise therapy vs home exercises

Pain‐free walking distance · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 322 participants
Moderate

Supervised exercise therapy vs home exercises

Quality of Life: SF‐36 (physical component) · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 68 participants
Low

Supervised exercise therapy vs home exercises

Health‐related quality of life (mental) · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 68 participants
Low

Supervised exercise therapy vs home exercises

Self‐reported functional impairment after 3 months (Walking Impairment Questionnaire combined) Scale: 1 to 100 (higher scores indicate better walking) · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

Supervised exercise therapy vs walking advice

Maximal treadmill walking distance after 3 months · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 624 participants
High

Supervised exercise therapy vs walking advice

Pain‐free walking distance · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 508 participants
High

Supervised exercise therapy vs walking advice

Quality of Life: SF‐36 (physical component) · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 296 participants
Low

Supervised exercise therapy vs walking advice

Health‐related quality of life (mental) · intermittent claudication

1 finding from 1 review

Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 296 participants
Low

Endovascular revascularisation vs no therapy

Maximum walking distance · intermittent claudication

2 findings from 1 review

Endovascular revascularisation versus conservative management for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 125 participants
Moderate
Endovascular revascularisation versus conservative management for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 103 participants
Low

Endovascular revascularisation vs conservative therapy

Pain‐free walking distance · intermittent claudication

2 findings from 1 review

Endovascular revascularisation versus conservative management for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 147 participants
Moderate
Endovascular revascularisation versus conservative management for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 345 participants
Moderate

Endovascular revascularisation vs conservative therapy

Secondary invasive interventions · intermittent claudication

Endovascular revascularisation showed no clear difference in secondary invasive interventions compared with conservative therapy (high certainty).

1 finding from 1 review

Endovascular revascularisation versus conservative management for intermittent claudication 2018 · Cochrane Headline outcomes only
OR 1.4 [0.7, 2.8]
4 studies · 395 participants
High

Endovascular revascularisation vs conservative therapy

Disease‐specific quality of life · intermittent claudication

1 finding from 1 review

Endovascular revascularisation versus conservative management for intermittent claudication 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 301 participants
High