Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

573 questions · 608 findings · 115 reviews

No studies found 136 · 22.4%GRADE not reported 54 · 8.9%Very low 166 · 27.3%Low 152 · 25%Moderate 75 · 12.3%High 25 · 4.1%

H2 receptor antagonists vs placebo or no prophylaxis

Clinically important upper GI bleeding · people admitted to intensive care units

H2 receptor antagonists probably leads to lower clinically important upper GI bleeding compared with placebo or no prophylaxis (moderate certainty).

1 finding from 1 review

Bispectral index vs treatment guided by clinical assessment alone?

Duration of mechanical ventilation · Mechanically ventilated adults in the intensive care unit

BIS monitoring showed no clear difference in duration of mechanical ventilation (measured in days) compared with clinical assessment (low certainty).

1 finding from 1 review

Thrombopoietin mimetics vs placebo or usual care

Number of participants with at least 1 bleeding episode · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether thrombopoietin mimetics changes number of participants with at least 1 bleeding episode compared with placebo or standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants with severe or life‐threatening bleeding · people with haematological disorders undergoing intensive chemotherapy or stem cell transplantation

It is very uncertain whether the intervention changes number of participants with severe or life‐threatening bleeding (very low certainty).

1 finding from 1 review