Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,970 questions · 2,433 findings · 231 reviews

No studies found 303 · 12.5%GRADE not reported 759 · 31.2%Very low 357 · 14.7%Low 476 · 19.6%Moderate 418 · 17.2%High 120 · 4.9%

1000 mg/day omega‐3 fatty acid from flaxseed oil supplement vs placebo

Ulcer healing · people with diabetes and foot ulcers

It is very uncertain whether 1000 mg/day omega‐3 fatty acid from flaxseed oil supplement changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

3 findings from 1 review

Magnesium and vitamin E co‐supplementation vs placebo

Ulcer healing · people with diabetes and foot ulcers

It is very uncertain whether magnesium and vitamin E co‐supplementation changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

2 findings from 1 review

Magnesium and vitamin E co‐supplementation vs placebo

Ulcer healing (absolute change in individual parameters of ulcer dimensions over time: mean (SD) cm wound width reduction · people with diabetes and foot ulcers

It is very uncertain whether magnesium and vitamin E co‐supplementation changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

1 finding from 1 review

Vitamin D vs placebo

Ulcer healing (absolute change in individual parameters of ulcer dimensions over time: mean (SD) cm wound length reduction · people with diabetes and foot ulcers

It is very uncertain whether vitamin D changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

1 finding from 1 review

Vitamin D vs placebo

Ulcer healing (absolute change in individual parameters of ulcer dimensions over time: mean (SD) cm wound depth reduction · people with diabetes and foot ulcers

It is very uncertain whether vitamin D changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

1 finding from 1 review

Vitamin D vs placebo

Ulcer healing (absolute change in individual parameters of ulcer dimensions over time: mean (SD) cm wound width reduction · people with diabetes and foot ulcers

It is very uncertain whether vitamin D changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

1 finding from 1 review

Valproate vs lithium

Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in individual adverse events ‐ Sedation At 3 weeks (secondary… compared with lithium (low certainty).

1 finding from 1 review

Valproate vs lithium

Adverse events: somnolence/sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 8 weeks (secondary… compared with lithium (very low certainty).

1 finding from 1 review

Valproate vs placebo

Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in individual adverse events ‐ Sedation At 3‐8 weeks (secondary… compared with placebo (high certainty).

1 finding from 1 review

Valproate vs placebo

Adverse effects: 1. Sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 4 weeks (secondary… compared with placebo (very low certainty).

1 finding from 1 review