Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

381 questions · 383 findings · 97 reviews · Headline outcomes only

No studies found 54 · 14.1%GRADE not reported 36 · 9.4%Very low 116 · 30.3%Low 99 · 25.8%Moderate 60 · 15.7%High 18 · 4.7%

Anti‐TNF dose reduction vs anti‐TNF continuation

Number of serious adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF dose reduction showed no clear difference in number of serious adverse events compared with anti‐TNF continuation (low certainty).

1 finding from 1 review

Anti‐TNF dose reduction vs anti‐TNF continuation

Withdrawals due to adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF dose reduction showed no clear difference in withdrawals due to adverse events compared with anti‐TNF continuation (low certainty).

1 finding from 1 review