Total serious adverse events Duration: 1.75 to 3 years · patients with hypertension
First‐line thiazides showed no clear difference in total serious adverse events Duration: 1.75 to 3 years compared with first‐line calcium channel blockers (low certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth with mixed root development
The effect of MTA versus CH in teeth with mixed root development is very uncertain (very low certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in mature permanent teeth
MTA increases clinical and radiographic success versus CH in mature teeth (moderate certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
Biodentine had a significantly higher pulpotomy success rate than CEM (indirect comparison; numeric estimate not available); ungraded.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
MTA and CEM did not differ significantly in pulpotomy success (indirect comparison); ungraded.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
Biodentine had a significantly higher pulpotomy success rate than calcium hydroxide (indirect comparison; numeric estimate not available); ungraded.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
MTA had a significantly higher pulpotomy success rate than calcium hydroxide (indirect comparison; numeric estimate not available); ungraded.
1 finding from 1 review
Kidney failure · proteinuric CKD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hyperkalaemia · proteinuric CKD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Death · proteinuric CKD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cardiovascular events · proteinuric CKD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Doubling serum creatinine · proteinuric CKD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
AKI · proteinuric CKD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proteinuria · proteinuric CKD
1 finding from 1 review
eGFR · proteinuric CKD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
MTA and calcium hydroxide had similar clinical and radiographic pulpotomy success at 6 months (RR 1.00, 95% CI 0.94 to 1.06; 2 RCTs; ungraded).
2 findings from 1 review
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found no difference in pulpotomy success between MTA and calcium-enriched mixture (both 100% at 6 and 12 months; not pooled; ungraded).
1 finding from 1 review
Single RCT (Nosrat 2012, 118 roots): 100% clinical and radiographic success in both MTA and CEM at 6 and 12 months (MTA 53/53 then 54/54 roots; CEM 55/55 then 57/57 roots); no statistical difference between groups at…
1 study · 118 participants
GRADE not reported
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Biodentine showed no clear difference in clinical failure compared with calcium hydroxide (CH); GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Mineral trioxide aggregate (MTA) may leads to lower radiological failure compared with calcium hydroxide (CH) (low certainty).
2 findings from 1 review
RR 0.12 [0.04, 0.36]
4 studies · 150 participants
Low
No radiological failure in any participant; not estimable
1 study · 50 participants
GRADE not reported
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with calcium hydroxide (CH) (very low certainty).
1 finding from 1 review