Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

537 questions · 558 findings · 32 reviews · Gut

No studies found 134 · 24%GRADE not reported 11 · 2%Very low 143 · 25.6%Low 138 · 24.7%Moderate 106 · 19%High 26 · 4.7%

Intervention diet vs control diet

Induction of remission (timeframe not reported) ‐ Symptoms‐guided diet · Patients with active Crohn's disease

It is very uncertain whether intervention diet changes induction of remission (timeframe not reported) ‐ Symptoms‐guided diet compared with control diet (very low certainty).

1 finding from 1 review

Intervention not reported

OutcomesAnalysis 1.4 · Patients with active Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Failure to achieve clinical remission · Patients with active Crohn's disease

The intervention leads to lower failure to achieve clinical remission (high certainty).

1 finding from 1 review

Intervention not reported

Failure to achieve clinical response (70‐point response) · Patients with active Crohn's disease

The intervention leads to lower failure to achieve clinical response (70‐point response) (high certainty).

1 finding from 1 review

Intervention not reported

Failure to achieve clinical response (100‐point response) · Patients with active Crohn's disease

The intervention leads to lower failure to achieve clinical response (100‐point response) (high certainty).

1 finding from 1 review

Intervention not reported

Endoscopic response · Patients with active Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life (QoL) Inflammatory Bowel Disease Questionnaire (IBDQ) (scale: 32 to 224; higher score = better QoL) · Patients with active Crohn's disease
1 finding from 1 review

Intervention not reported

Adverse events · Patients with active Crohn's disease

The intervention showed no clear difference in adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · Patients with active Crohn's disease

The intervention showed no clear difference in serious adverse events (low certainty).

1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events · Patients with active Crohn's disease

The intervention showed no clear difference in withdrawals due to adverse events (low certainty).

1 finding from 1 review

Two infusions of natalizumab (300 mg or 3 mg/kg) vs placebo

Failure to induce clinical response (Panaccione 2010) CDAI ‐ (≥100 point reduction) · Patients with active Crohn's disease

Two infusions of natalizumab (300 mg or 3 mg/kg) showed no clear difference in failure to induce clinical response at 6 weeks compared with placebo (low certainty).

1 finding from 1 review