Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Rotarix vs placebo

Severe cases of rotavirus diarrhoea · children

Rotarix leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty).

6 findings from 1 review
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Rotarix vs placebo

Severe cases of all‐cause diarrhoea · children

Rotarix leads to lower severe cases of all‐cause diarrhoea compared with placebo (high certainty).

6 findings from 1 review
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Rotarix vs placebo

All‐cause death · children

Rotarix showed no clear difference in all‐cause death compared with placebo (moderate certainty).

3 findings from 1 review

Rotarix vs placebo

All serious adverse events · children

Rotarix leads to lower all serious adverse events compared with placebo (high certainty).

3 findings from 1 review

Rotarix vs placebo

Serious adverse events: intussusception · children

Rotarix showed no clear difference in serious adverse events: intussusception compared with placebo (low certainty).

3 findings from 1 review

RotaTeq vs placebo

Severe cases of rotavirus diarrhoea · children

RotaTeq leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty).

6 findings from 1 review
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RotaTeq vs placebo

Severe cases of all‐cause diarrhoea · children

The review found no eligible studies for this question.

6 findings from 1 review
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RotaTeq vs placebo

All‐cause death · children

RotaTeq showed no clear difference in all‐cause death compared with placebo (low certainty).

3 findings from 1 review

RotaTeq vs placebo

All serious adverse events · children

RotaTeq showed no clear difference in all serious adverse events compared with placebo (high certainty).

3 findings from 1 review

RotaTeq vs placebo

Serious adverse events: intussusception · children

RotaTeq showed no clear difference in serious adverse events: intussusception compared with placebo (low certainty).

3 findings from 1 review

Rotasiil vs placebo

Severe cases of all‐cause diarrhoea · children

Rotasiil showed no clear difference in severe cases of all‐cause diarrhoea compared with placebo (high certainty).

2 findings from 1 review