Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,771 questions · 10,185 findings · 893 reviews

No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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HVGIC with chlorhexidine cavity disinfectant vs HVGIC without cavity disinfectant

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; cavity disinfectant did not affect success in the review narrative.

1 finding from 1 review

Amalgam vs Light-cured compomer (polyacid-modified composite resin)

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; the review described similar clinical performance.

1 finding from 1 review

Compomer (Dyract) vs HVGIC Equia Forte and Chemfil Rock

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; compomer had more favorable retention in the review narrative.

1 finding from 1 review

ART/HAART duration <3 years vs ART/HAART duration >=3 years

Oral candidiasis · Children and adolescents living with HIV on ART/HAART

Oral candidiasis prevalence differed by ART duration (OR 17.93, 95% CI 3.69 to 83.12).

1 finding from 1 review

Resin-modified glass ionomer cement for bonding orthodontic brackets vs Compomer and composite resin

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; failure rates were tabulated by arm.

1 finding from 1 review

Flowable bulk-fill composite resin vs Light-cured compomer (polyacid-modified composite resin)

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; both arms had 0% failure.

1 finding from 1 review

Antiplatelet drug vs control

Recurrent ischaemic or unknown stroke during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes recurrent ischaemic/unknown stroke during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Symptomatic intracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes symptomatic intracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Major extracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes major extracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Complete recovery from stroke (post hoc) · acute ischaemic stroke

Antiplatelet drug probably leads to higher complete recovery from stroke (post hoc) compared with control (moderate certainty).

1 finding from 1 review

Summary of findings: colistimethate dry powder for inhalation (Colobreathe®) vs tobramycin

Pulmonary exacerbations · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: colistimethate dry powder for inhalation… showed no clear difference in pulmonary exacerbations: number of pulmonary exacerbations compared with tobramycin (moderate certainty).

1 finding from 1 review