Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,584 questions · 3,695 findings · 567 reviews

No studies found 784 · 21.2%GRADE not reported 308 · 8.3%Very low 1,036 · 28%Low 971 · 26.3%Moderate 440 · 11.9%High 156 · 4.2%

FAE vs placebo

PASI score (scale range from 0 to 72 (higher score indicates more severe psoriasis)) · psoriasis
1 finding from 1 review

FAE vs MTX

Common nuisance AEs (not leading to treatment discontinuation) · psoriasis

It is very uncertain whether FAE changes common nuisance AEs (not leading to treatment discontinuation) compared with MTX (very low certainty).

1 finding from 1 review

FAE vs MTX

PASI 50 · psoriasis

It is very uncertain whether FAE changes PASI 50 compared with MTX (very low certainty).

1 finding from 1 review

FAE vs MTX

Percentage of participants reaching PASI 75 · psoriasis

It is very uncertain whether FAE changes PASI 75 compared with MTX (very low certainty).

1 finding from 1 review

FAE vs MTX

PASI 90 · psoriasis

It is very uncertain whether FAE changes PASI 90 compared with MTX (very low certainty).

1 finding from 1 review

FAE vs placebo

Common nuisance AEs (not leading to treatment discontinuation) · psoriasis

FAE probably leads to higher common nuisance AEs (not leading to treatment discontinuation) compared with placebo (moderate certainty).

1 finding from 1 review

FAE vs MTX

PASI score (scale range from 0 to 72 (higher score indicates more severe psoriasis)) · psoriasis
1 finding from 1 review

FAE vs MTX

Withdrawals due to adverse events · psoriasis

It is very uncertain whether FAE changes AEs leading to treatment discontinuation compared with MTX (very low certainty).

1 finding from 1 review