Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,678 questions · 4,859 findings · 283 reviews

No studies found 1,225 · 25.2%GRADE not reported 215 · 4.4%Very low 1,241 · 25.5%Low 1,210 · 24.9%Moderate 776 · 16%High 192 · 4%

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Adverse events (moderate) · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes adverse events moderate adverse events experienced during and after… compared with IV antibiotics only (very low certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Microbiology Emergence of resistant organisms · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics plus IV antibiotics changes microbiology Emergence of resistant organisms compared with IV antibiotics only (very low certainty).

1 finding from 1 review

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Quality of life: number of participants achieving MCID · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

Summary of findings: Inhaled antibiotics plus IV antibiotics showed no clear difference in quality of life: number of participants achieving MCID compared with IV antibiotics only (low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs usual care

Change in arterial partial pressure of oxygen · stable COPD
2 findings from 1 review

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

Change in arterial partial pressure of oxygen · post‐exacerbation COPD
2 findings from 1 review

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

Change in arterial partial pressure of carbon dioxide · post‐exacerbation COPD
2 findings from 1 review

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

Change in the health‐related quality of life · post‐exacerbation COPD
2 findings from 1 review

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

Admission‐free survival · post‐exacerbation COPD

Summary of Findings Table ‐ Chronic non‐invasive ventilation may leads to lower admission‐free survival compared with standard treatment following a severe exacerbation (low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

All‐cause mortality · post‐exacerbation COPD

Summary of Findings Table ‐ Chronic non‐invasive ventilation showed no clear difference in all‐cause mortality compared with standard treatment following a severe exacerbation (low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs usual care

Change in arterial partial pressure of carbon dioxide · stable COPD
2 findings from 1 review