Number of participants with ≥ 75% reduction in all seizures · Lennox‐Gastaut syndrome, any age
Topiramate plus ASMs showed no clear difference in number of participants with ≥ 75% reduction in all seizures compared with placebo plus ASMs (low certainty).
1 finding from 1 review
50% or greater reduction in seizure frequency · Lennox‐Gastaut syndrome, any age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age
1 finding from 1 review
Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age
Cannabidiol (10 mg/kg and 20 mg/kg) plus ASMs leads to higher number of participants with adverse events leading to study… compared with placebo plus ASMs (high certainty).
1 finding from 1 review
Seizure freedom · Lennox‐Gastaut syndrome, any age
1 finding from 1 review
Number of participants with ≥ 75% reduction in mean weekly seizures · Lennox‐Gastaut syndrome, any age
It is very uncertain whether cinromide plus ASMs changes number of participants with ≥ 75% reduction in mean weekly seizures compared with placebo plus ASMs (very low certainty).
1 finding from 1 review
50% or greater reduction in seizure frequency · Lennox‐Gastaut syndrome, any age
It is very uncertain whether cinromide plus ASMs changes number of participants with ≥ 50% reduction in mean weekly seizures compared with placebo plus ASMs (very low certainty).
1 finding from 1 review
Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Seizure freedom · Lennox‐Gastaut syndrome, any age
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Incidence of S pneumoniae infection Isolated bacterial infection · children with SCD
Summary of findings ‐ initiation of penicillin prophylaxis may leads to lower incidence of S pneumoniae infection Isolated bacterial infection compared with placebo (low certainty).
1 finding from 1 review
Deaths · children with SCD
Summary of findings ‐ initiation of penicillin prophylaxis showed no clear difference in deaths compared with placebo (low certainty).
1 finding from 1 review
Adverse effects · children with SCD
1 finding from 1 review
Antibiotic‐resistant organisms isolated · children with SCD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Requirement of other courses of antibiotics · children with SCD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Compliance with treatment · children with SCD
1 finding from 1 review
All‐cause mortality maximum · patients with coronary heart disease
Antibiotics showed no clear difference in all‐cause mortality at maximum compared with placebo or no intervention (high certainty).
1 finding from 1 review
Quality of life at 24±6 months · patients with coronary heart disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cardiovascular mortality · patients with coronary heart disease
Antibiotics leads to higher cardiovascular mortality at 24±6 months compared with placebo or no intervention (high certainty).
2 findings from 1 review
Myocardial infarction · patients with coronary heart disease
Antibiotics showed no clear difference in myocardial infarction at 24±6 months compared with placebo or no intervention (moderate certainty).
2 findings from 1 review
Stroke · patients with coronary heart disease
Antibiotics showed no clear difference in stroke at 24±6 months compared with placebo or no intervention (high certainty).
2 findings from 1 review