What do systematic reviews say?

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

A single study found no significant difference in S. mutans presence between aligners and fixed appliances in adolescents at 1 month (RR 0.86, 95% CI 0.64 to 1.14; ungraded).

• Impact of Aligners and Fixed Appliances on Oral Health during Orthodontic Treatment: A Systematic Review and… 2021 All outcomes

  1 month · Adolescents
  RR 0.86 [0.64, 1.14]
  1 study
  GRADE not reported

Dietary advice vs no advice

Dietary advice showed no clear difference in mortality compared with no advice (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.87 [0.26, 2.96]
  7 studies · 574 participants
  Low

Dietary advice vs no advice

The review found no eligible studies for this question.

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dietary advice plus supplements vs no advice

Dietary advice plus supplements if required showed no clear difference in mortality compared with no advice (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.82 [0.58, 1.16]
  15 studies · 1261 participants
  Low

Dietary advice plus supplements vs no advice

Dietary advice plus supplements if required showed no clear difference in number of people admitted or re‐admitted to hospital compared with no advice (moderate certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.83 [0.59, 1.15]
  7 studies · 673 participants
  Moderate

Dietary advice plus supplements vs no advice

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 400 participants
  Low

Dietary advice plus supplements vs no advice

Dietary advice plus supplements if required showed no clear difference in complications compared with no advice (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.56 [0.22, 1.46]
  2 studies · 280 participants
  Low

Dietary advice plus supplements vs no advice

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  17 studies · 1192 participants
  Moderate

Dietary advice plus supplements vs no advice

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 262 participants
  Low

Dietary advice plus supplements vs no advice

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 389 participants
  Low

Dietary advice plus supplements vs no dietary advice plus no supplements

Dietary advice plus supplements showed no clear difference in mortality compared with no dietary advice plus no supplements (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.91 [0.55, 1.52]
  7 studies · 797 participants
  Low

Dietary advice vs no advice

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 148 participants
  Low

Dietary advice plus supplements vs no dietary advice plus no supplements

The review found no eligible studies for this question.

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dietary advice plus supplements vs no dietary advice plus no supplements

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 258 participants
  Low

Dietary advice plus supplements vs no dietary advice plus no supplements

Dietary advice plus supplements may leads to lower complications compared with no dietary advice plus no supplements (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.42 [0.2, 0.89]
  1 study · 50 participants
  Low

Dietary advice plus supplements vs no dietary advice plus no supplements

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 620 participants
  Low

Dietary advice plus supplements vs no dietary advice plus no supplements

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 130 participants
  Very low

Dietary advice plus supplements vs no dietary advice plus no supplements

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 357 participants
  Very low

Dietary advice vs no advice

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 148 participants
  Low

Dietary advice vs no advice

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 802 participants
  Low