Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Mohs micrographic surgery vs surgical excision

Recurrence · adults with basal cell carcinoma of the skin

Mohs micrographic surgery showed no clear difference in recurrence at 3 years compared with surgical excision (low certainty).

2 findings from 1 review

Radiotherapy vs surgical excision

Recurrence · adults with basal cell carcinoma of the skin

Radiotherapy may leads to higher recurrence at 3 years compared with surgical excision (with or without frozen section margin control) (low certainty).

2 findings from 1 review

Radiotherapy vs surgical excision

Cosmetic outcome (good/excellent) · adults with basal cell carcinoma of the skin

Radiotherapy probably leads to lower cosmetic outcome (good/excellent) compared with surgical excision (with or without frozen section margin control) (moderate certainty).

1 finding from 1 review

Imiquimod vs MAL‐PDT

Recurrence · adults with basal cell carcinoma of the skin

Imiquimod cream probably leads to lower recurrence at 3 years compared with MAL‐PDT (moderate certainty).

2 findings from 1 review

Imiquimod vs MAL‐PDT

Cosmesis · adults with basal cell carcinoma of the skin

Imiquimod cream showed no clear difference in cosmetic outcome (excellent/good) compared with MAL‐PDT (moderate certainty).

1 finding from 1 review

Imiquimod vs MAL‐PDT

Number of patients with moderate/severe pain (1 hour postoperatively) · adults with basal cell carcinoma of the skin

Imiquimod cream probably leads to lower pain (moderate/severe) compared with MAL‐PDT (moderate certainty).

1 finding from 1 review

Imiquimod vs MAL‐PDT

Early treatment failure · adults with basal cell carcinoma of the skin

Imiquimod cream showed no clear difference in early treatment failure compared with MAL‐PDT (moderate certainty).

1 finding from 1 review

Imiquimod vs surgical excision

Recurrence · adults with basal cell carcinoma of the skin

Imiquimod probably leads to higher recurrence at 3 years compared with surgical excision (moderate certainty).

2 findings from 1 review

Imiquimod vs surgical excision

Number of patients with moderate/severe pain (1 hour postoperatively) · adults with basal cell carcinoma of the skin

Imiquimod showed no clear difference in pain (moderate/severe) compared with surgical excision (low certainty).

1 finding from 1 review