Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

480 questions · 494 findings · 38 reviews

No studies found 118 · 23.9%GRADE not reported 54 · 10.9%Very low 176 · 35.6%Low 99 · 20%Moderate 34 · 6.9%High 13 · 2.6%

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Global outcome: no overall improvement ‐ at 30 minutes · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: no overall improvement ‐ at 30 minutes compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Adverse effects: specific ‐ dystonia · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ dystonia (only reported if occurred in… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Adverse effects: Specific ‐ hypertonia/rigidity (only reported if occurred in ≥9%) during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ hypertonia/rigidity (only reported if… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ARIPIPRAZOLE

Adverse effects: any serious, specific ‐ dystonia during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: any serious, specific ‐ dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

Repeated need for tranquillisation ‐ not reported · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes repeated need for tranquillisation compared with COMBINATIONS: c. HALOPERIDOL + MIDAZOLAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: c. HALOPERIDOL + PROMETHAZINE

Repeated need for tranquillisation ‐ not reported · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes repeated need for tranquillisation compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (very low certainty).

1 finding from 1 review