Incidence of depression ‐ post‐intervention: 0 months · adults with long‐term physical conditions (18 years or older)
It is very uncertain whether pharmacological interventions changes incidence of depression ‐ post‐intervention: 0 months compared with placebo (very low certainty).
1 finding from 1 review
Successful discontinuation rate · participants with depressive or anxiety disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Relapse · participants with depressive or anxiety disorders
It is very uncertain whether abrupt discontinuation changes relapse (as defined by study authors) (HR) compared with continuation of long‐term antidepressants (very low certainty).
1 finding from 1 review
Withdrawal symptoms · participants with depressive or anxiety disorders
1 finding from 1 review
Adverse events · participants with depressive or anxiety disorders
It is very uncertain whether abrupt discontinuation changes adverse events compared with continuation of long‐term antidepressants (very low certainty).
1 finding from 1 review
Anxiety · participants with depressive or anxiety disorders
1 finding from 1 review
Quality of life · participants with depressive or anxiety disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Social and occupational functioning · participants with depressive or anxiety disorders
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proportion of individuals with a diagnosis of: PTSD, anxiety, depression, and somatic symptom and related disorders · children and adolescents exposed to traumatic events;
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Depression at endpoint · adults (aged 18 and older) exposed to a traumatic event
1 finding from 1 review
Depression at endpoint · children and adolescents exposed to traumatic events;
1 finding from 1 review
Proportion of individuals with a diagnosis of: PTSD, anxiety, depression, and somatic symptom and related disorders · adults (aged 18 and older) exposed to a traumatic event
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Depressive symptoms · various
1 finding from 1 review
Depressive symptoms · various
1 finding from 1 review
Leaving the study early · treatment‐resistant depression in adults
Switching to mianserin (60 mg/d) showed no clear difference in dropouts compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).
1 finding from 1 review
Response (> 50% improvement on 29‐item HAM‐D SIGH‐SAD) · treatment‐resistant depression in adults
Switching to mianserin (60 mg/d) showed no clear difference in response (≥ 50% improvement in HAM‐D score) compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).
1 finding from 1 review
Remission (HAM‐D total score ≤ 8) · treatment‐resistant depression in adults
Switching to mianserin (60 mg/d) showed no clear difference in remission (HAM‐D total score ≤ 8) compared with continuing on current antidepressant (fluoxetine 20 mg/d) (low certainty).
1 finding from 1 review
Quality of life ‐ not measured · treatment‐resistant depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Severity of depression (SIGH‐SAD score) at the end of the study · adults with a history of SAD
1 finding from 1 review
Change in depressive symptoms · patients with chronic obstructive pulmonary disease
1 finding from 1 review