Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

469 questions · 483 findings · 63 reviews

No studies found 117 · 24.2%GRADE not reported 13 · 2.7%Very low 68 · 14.1%Low 141 · 29.2%Moderate 112 · 23.2%High 32 · 6.6%

Clobazam vs phenytoin

Seizure freedom · drug‐naïve people with focal or generalized seizures with solitary cysticercus granuloma

The review found no eligible studies for this question.

2 findings from 1 review

Clobazam vs phenytoin

Adverse effects requiring withdrawal/discontinuation of study medication · drug‐naïve people with focal or generalized seizures with solitary cysticercus granuloma

Clobazam showed no clear difference in adverse effects requiring withdrawal/discontinuation of study… compared with phenytoin (low certainty).

1 finding from 1 review

Clobazam vs carbamazepine

Seizure freedom · people with focal or generalized seizures

Clobazam showed no clear difference in seizure freedom at 4 weeks compared with carbamazepine (low certainty).

2 findings from 1 review

Clobazam vs phenytoin

Time on allocated treatment (retention time) · drug‐naïve people with focal or generalized seizures with solitary cysticercus granuloma

The review found no eligible studies for this question.

1 finding from 1 review

Clobazam vs phenytoin

Retention [ · drug‐naïve people with focal or generalized seizures with solitary cysticercus granuloma

Clobazam may leads to higher retention at 6 months (measured by the number of treatment failures… compared with phenytoin (low certainty).

1 finding from 1 review

Hearing aid vs sound generator

Tinnitus symptom severity · adults with tinnitus
3 findings from 1 review

Intervention not reported

Time to treatment withdrawal ‐ all participants Range of · adults and children with newly diagnosed partial onset or generalised onset seizures

The intervention may leads to higher time to treatment withdrawal ‐ all participants Range of (low certainty).

1 finding from 1 review

Intervention not reported

Time to first seizure ‐ all participants Range of · adults and children with newly diagnosed partial onset or generalised onset seizures

The intervention showed no clear difference in time to first seizure ‐ all participants Range of (moderate certainty).

1 finding from 1 review

Intervention not reported

Time to first seizure ‐ stratified by epilepsy type ‐ Partial onset Range of · adults and children with newly diagnosed partial onset or generalised onset seizures

The intervention showed no clear difference in time to first seizure ‐ stratified by epilepsy type ‐ Partial onset… (moderate certainty).

1 finding from 1 review

Intervention not reported

Time to treatment withdrawal ‐ stratified by seizure type ‐ Partial onset Range of · adults and children with newly diagnosed partial onset or generalised onset seizures

The intervention may leads to higher time to treatment withdrawal ‐ stratified by seizure type ‐ Partial… (low certainty).

1 finding from 1 review

Intervention not reported

Time to 12‐month remission ‐ all participants Range of · adults and children with newly diagnosed partial onset or generalised onset seizures

The intervention showed no clear difference in time to 12‐month remission ‐ all participants Range of (moderate certainty).

1 finding from 1 review