Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

343 questions · 360 findings · 49 reviews

No studies found 95 · 26.4%GRADE not reported 16 · 4.4%Very low 45 · 12.5%Low 121 · 33.6%Moderate 76 · 21.1%High 7 · 1.9%

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in HIV transmission at 28 weeks among those whose diagnostic testing… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infant mortality at 28 weeks among those whose diagnostic testing… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in HIV transmission or death at 28 weeks among those whose diagnostic… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

Infants with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infants with Severe Adverse Events compared with an extended NVP regimen administered to infants (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

Mothers with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… may leads to higher mothers with Severe Adverse Events compared with an extended NVP regimen administered to infants (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infants with Probably Related Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP regimen administered to infants for 14 weeks changes infants with Probably Related Severe Adverse Events11 compared with sdNVP plus ZDV (1week) (very low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

HIV Transmission at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV regimen administered to infants for 14 weeks probably leads to lower HIV Transmission at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1 week) (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Nipple stimulation (suckling) vs no treatment (comparison 1)

Maternal death · nipple stimulation (suckling) for preventing postpartum haemorrhage in the third stage of labour.

It is very uncertain whether summary of findings ‐ Nipple stimulation (suckling) changes maternal death compared with no treatment (comparison 1) (very low certainty).

1 finding from 1 review

Summary of findings ‐ Nipple stimulation (suckling) vs no treatment (comparison 1)

Frequency of PPH ≥ 500 mL · nipple stimulation (suckling) for preventing postpartum haemorrhage in the third stage of labour.

Summary of findings ‐ Nipple stimulation (suckling) showed no clear difference in frequency of PPH ≥ 500 mL compared with no treatment (comparison 1) (moderate certainty).

1 finding from 1 review

Summary of findings ‐ Nipple stimulation (suckling) vs no treatment (comparison 1)

Retained placenta · nipple stimulation (suckling) for preventing postpartum haemorrhage in the third stage of labour.

It is very uncertain whether summary of findings ‐ Nipple stimulation (suckling) changes retained placenta compared with no treatment (comparison 1) (very low certainty).

1 finding from 1 review

Summary of findings ‐ Nipple stimulation (suckling) vs no treatment (comparison 1)

Perinatal mortality · nipple stimulation (suckling) for preventing postpartum haemorrhage in the third stage of labour.

Summary of findings ‐ Nipple stimulation (suckling) showed no clear difference in perinatal death compared with no treatment (comparison 1) (low certainty).

1 finding from 1 review