Findings

What do systematic reviews say?

1,036 questions · 1,100 findings · 261 reviews

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No studies found 160 · 14.5%GRADE not reported 188 · 17.1%Very low 270 · 24.5%Low 303 · 27.5%Moderate 139 · 12.6%High 40 · 3.6%

Intervention not reported

Gait assessment · participants with CTEV at initial presentation

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for congenital talipes equinovarus (clubfoot) 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Gait assessment · participants with resistant CTEV

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for congenital talipes equinovarus (clubfoot) 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral progestogen (dienogest, desogestrel) vs goserelin acetate

Uterine fibroid‐related symptoms (abnormal uterine bleeding, measured at 12 weeks, with the pictorial blood assessment chart (PBAC); lower = better) · women with uterine fibroids

1 finding from 1 review

Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

LNG‐IUS vs another combined low‐dose OCP

Uterine fibroid‐related symptoms (abnormal uterine bleeding, measured at 12 weeks, with the pictorial blood assessment chart (PBAC); lower = better) · women with uterine fibroids

1 finding from 1 review

Progestogens or progestogen‐releasing intrauterine systems for uterine fibroids (other than preoperative medical… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low

Summary of findings ‐ computerised learning vs no intervention

QoL · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Benzoyl peroxide vs placebo or no treatment

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide may leads to higher participant's global self‐assessment of improvement (long‐term data) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
RR 1.27 [1.12, 1.45]
3 studies · 2234 participants
Low

Benzoyl peroxide vs erythromycin

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzoyl peroxide vs salicylic acid

Participant's global self‐assessment of improvement (long‐term data) ‐ not measured · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzoyl peroxide vs adapalene

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with adapalene (low certainty).

1 finding from 1 review

Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
RR 0.99 [0.9, 1.1]
5 studies · 1472 participants
Low

Benzoyl peroxide vs clindamycin

Participant's global self‐assessment of improvement (long‐term data) · participants with acne

Benzoyl peroxide showed no clear difference in participant's global self‐assessment of improvement (long‐term data) compared with clindamycin (low certainty).

1 finding from 1 review

Topical benzoyl peroxide for acne 2020 · Cochrane Headline outcomes only
RR 0.95 [0.68, 1.34]
1 study · 240 participants
Low

Radioembolisation plus sorafenib vs sorafenib monotherapy

Tumour response measures · people with hepatocellular carcinoma

The review found no eligible studies for this question.

1 finding from 1 review

Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Azelaic acid vs adapalene

Participants' global self‐assessment of acne improvement · participants with acne

It is very uncertain whether azelaic acid changes participants' global self‐assessment of acne improvement Improved to… compared with adapalene (very low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 0.89 [0.68, 1.17]
1 study · 55 participants
Very low

Azelaic acid vs tretinoin

Participants' global self‐assessment of acne improvement Good to excellent improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid showed no clear difference in participants' global self‐assessment of acne improvement Good to… compared with tretinoin (moderate certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 0.94 [0.78, 1.14]
1 study · 289 participants
Moderate

Salicylic acid vs benzoyl peroxide

Participants' global self‐assessment of acne improvement · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Salicylic acid vs pyruvic acid

Participants' global self‐assessment of acne improvement Good to excellent improvement (medium term: treatment duration from 5 to 8 weeks) · participants with acne

It is very uncertain whether salicylic acid changes participants' global self‐assessment of acne improvement Good to… compared with pyruvic acid (very low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 1.12 [0.68, 1.84]
1 study · 86 participants
Very low

Salicylic acid vs tretinoin

Participants' global self‐assessment of acne improvement Moderate to excellent improvement (long term: treatment duration > 8 weeks) · participants with acne

Salicylic acid showed no clear difference in participants' global self‐assessment of acne improvement Moderate to… compared with tretinoin (low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 1 [0.92, 1.09]
1 study · 46 participants
Low

Nicotinamide vs clindamycin

Participants' global self‐assessment of acne improvement · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Nicotinamide vs erythromycin

Participants' global self‐assessment of acne improvement · participants with acne

The review found no eligible studies for this question.

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Glycolic acid (alpha‐hydroxy acid) vs salicylic‐mandelic acid

Participants' global self‐assessment of acne improvement Fair to good improvement (long term: treatment duration > 8 weeks) · participants with acne

Glycolic acid (alpha‐hydroxy acid) showed no clear difference in participants' global self‐assessment of acne improvement Fair to… compared with salicylic‐mandelic acid (low certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 1.06 [0.88, 1.26]
1 study · 40 participants
Low

Azelaic acid vs benzoyl peroxide

Participants' global self‐assessment of acne improvement Good or very good improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid probably leads to lower participants' global self‐assessment of acne improvement Good or… compared with benzoyl peroxide (moderate certainty).

1 finding from 1 review

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha‐hydroxy acid) for acne 2020 · Cochrane Headline outcomes only
RR 0.82 [0.72, 0.95]
1 study · 351 participants
Moderate