evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

Ranked among the 5,000 newest matching findings; add words or filters to narrow the search.

Rufinamide plus ASMs vs placebo plus ASMs

Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age

Rufinamide plus ASMs showed no clear difference in number of participants with adverse events leading to study… compared with placebo plus ASMs (low certainty).

1 finding from 1 review

Cannabidiol (10 mg/kg and 20 mg/kg) plus ASMs vs placebo plus ASMs

Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age

Cannabidiol (10 mg/kg and 20 mg/kg) plus ASMs leads to higher number of participants with adverse events leading to study… compared with placebo plus ASMs (high certainty).

1 finding from 1 review

Cinromide plus ASMs vs placebo plus ASMs

Number of participants with ≥ 75% reduction in mean weekly seizures · Lennox‐Gastaut syndrome, any age

It is very uncertain whether cinromide plus ASMs changes number of participants with ≥ 75% reduction in mean weekly seizures compared with placebo plus ASMs (very low certainty).

1 finding from 1 review

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Incidence of S pneumoniae infection Isolated bacterial infection · children with SCD

Summary of findings ‐ initiation of penicillin prophylaxis may leads to lower incidence of S pneumoniae infection Isolated bacterial infection compared with placebo (low certainty).

1 finding from 1 review