On‐study mortality3 (Subnet based on 55 studies including 15,074 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in on‐study mortality3 (Subnet based on 55 studies including 15,074… compared with no treatment (low certainty).
1 finding from 1 review
RR 0.13 [0.01, 2.29]
Studies not reported
Low
Haemoglobin response (Subnet based on 31 studies including 6985 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron probably leads to higher haemoglobin response (Subnet based on 31 studies including 6985… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 6.71 [4.93, 9.14]
Studies not reported
Moderate
Red blood cell transfusions (Subnet based on 69 studies including 18,684 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron probably leads to lower red blood cell transfusions (Subnet based on 69 studies including… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 0.44 [0.31, 0.63]
Studies not reported
Moderate
Overall mortality4 (Subnet based on 71 studies including 21,576 participants) · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in overall mortality4 (Subnet based on 71 studies including 21,576… compared with no treatment (low certainty).
1 finding from 1 review
RR 1.46 [0.87, 2.43]
Studies not reported
Low
Thromboembolic events · patients at any age with solid cancer or haematological malignancy
ESA with or without iron showed no clear difference in thromboembolic events5 (Subnet based on 50 studies including 15,408… compared with no treatment (moderate certainty).
1 finding from 1 review
RR 1.82 [0.98, 3.41]
Studies not reported
Moderate
Thrombocytopenia or haemorrhage5 (Subnet based on 13 studies including 2744 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Hypertension5 (Subnet based on 24 studies including 8383 participants) · patients at any age with solid cancer or haematological malignancy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Angular cheilitis (WHO clinical stage 2) · Children or adolescents
No significant difference in angular cheilitis prevalence between CLWH and healthy controls (pooled OR 1.95, 95% CI 0.16 to 23.65).
1 finding from 1 review
Number of caries in primary teeth (dt index) · School children, primary school in Saudi Arabia
It is very uncertain whether referral to a specific dental treatment facility changes number of caries in primary teeth (dt index) compared with generic advice letter to see a dentist (very low certainty).
1 finding from 1 review
Adverse events · School children (aged 4 to 15 years), primary and secondary schools in the UK and India
The review found no eligible studies for this question.
1 finding from 1 review
Mucosal hyperpigmentation prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in mucosal hyperpigmentation between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.79 [0.89, 3.61]
Studies not reported
Very low
Dental caries prevalence · School children (aged 4 to 15 years), primary and secondary schools in the UK and India
1 finding from 1 review
Milsom 2006 measured prevalence of dental caries as mean number of teeth with active caries in primary teeth (dt) and permanent teeth (DT); post-intervention changes from baseline were not significant, and the authors…
1 study · 16684 participants
GRADE not reported
Number of caries in permanent teeth (DT index) · School children, primary school in Saudi Arabia
It is very uncertain whether referral to a specific dental treatment facility changes number of caries in permanent teeth (DT index) compared with generic advice letter to see a dentist (very low certainty).
1 finding from 1 review
Gingivitis · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in gingivitis between ART regimens (very low certainty).
1 finding from 1 review
Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in chronic herpes simplex infection between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 2.47 [0.88, 6.97]
Studies not reported
Very low
Dental attendance · primary or secondary school pupils
Criteria-based screening (dentist refers using pre-established… showed no clear difference in dental attendance compared with no screening (low certainty).
1 finding from 1 review
Linear gingival erythema (WHO clinical stage 2) · Children or adolescents
No difference in linear gingival erythema between groups (pooled OR 1.00, 95% CI 0.06 to 16.19); the lesion was essentially absent in both groups.
1 finding from 1 review
Cost‐effectiveness · School children (aged 4 to 15 years), primary and secondary schools in the UK and India
The review found no eligible studies for this question.
1 finding from 1 review
Proportion of children with treated/untreated caries (receipt of dental care) · School children, primary schools in the USA
It is very uncertain whether referral letter based on the common-sense model (CSM) of… changes proportion of children with treated/untreated caries (receipt of… compared with standard referral letter (very low certainty).
1 finding from 1 review
Caries experience · Children and adolescents (<18 years) living with HIV (CLWH)
ART was not associated with a significant difference in dental caries experience among CLWH (very low certainty).
1 finding from 1 review