Findings

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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Early extraction of a compromised first permanent molar vs Contralateral non-extraction side (same patient)

Development and eruption of the second permanent molar · Children aged 5 to 15 years with a compromised first permanent molar

Root closure and eruption of the second permanent molar appeared accelerated on the extraction side in a single case-control study; ungraded and not statistically tested.

1 finding from 1 review

Late treatment (one-phase) with removable functional appliance vs no treatment

Incidence of incisal trauma · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

The review found no eligible studies for this question.

1 finding from 1 review

Removable functional appliance vs Fixed functional appliance

Final overjet · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Removable functional appliance may leads to higher final overjet compared with fixed functional appliance (low certainty).

1 finding from 1 review

Midazolam (any mode of delivery) vs Different dosage of the same sedative

Behaviour · Children and adolescents (0 to 16 years) needing dental treatment
1 finding from 1 review
  • Any behavioural score - Midazolam (any mode of delivery): 394 (10 studies); VERY LOW. Insufficient evidence to determine whether any specific dose of intranasal midazolam is effective; weak evidence oral midazolam…
    10 studies · 394 participants
    Very low

Early extraction of a compromised mandibular first permanent molar vs Contralateral non-extraction side (same patient)

Development and eruption of the third molar · Children aged 5 to 15 years with a compromised first permanent molar

Development and eruption of the third molar appeared accelerated after early first permanent molar extraction in two studies (e.g., eruption OR 2.86, 95% CI 1.37 to 5.96); ungraded.

1 finding from 1 review

Ty21a vaccine (three doses) vs control

Cases of typhoid fever, Year 1 · adults and children aged 5 years of age and older

Ty21a vaccine (three doses) probably leads to lower cases of typhoid fever, Year 1 compared with control (moderate certainty).

2 findings from 1 review

Vi‐rEPA vaccine (2 doses) vs control

Incidence of typhoid fever – year 1 · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to lower incidence of typhoid fever – year 1 compared with control (moderate certainty).

1 finding from 1 review

Vi‐rEPA vaccine (2 doses) vs control

Incidence of typhoid fever – year 2 · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to lower incidence of typhoid fever – year 2 compared with control (moderate certainty).

1 finding from 1 review

Vi‐rEPA vaccine (2 doses) vs control

Fever · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to higher fever after Vi‐rEPA (dose1) compared with control (moderate certainty).

1 finding from 1 review

Vi‐rEPA vaccine (2 doses) vs control

Fever after Vi‐rEPA (dose2) · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to higher fever after Vi‐rEPA (dose2) compared with control (moderate certainty).

1 finding from 1 review

Vi‐rEPA vaccine (2 doses) vs control

Erythema · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) showed no clear difference in erythema after Vi‐rEPA (dose 2) compared with control (low certainty).

1 finding from 1 review

Vi‐rEPA vaccine (2 doses) vs control

Swelling at injection site after Vi‐rEPA (dose 2) · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to higher swelling at injection site after Vi‐rEPA (dose 2) compared with control (moderate certainty).

1 finding from 1 review