Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs usual care

Economic: Increased costs of health care · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Dietary supplements (Catuama herbal compound) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months) · Catuama
    'Catuama' herbal compound (Spanemberg 2012) contributes to the dietary supplements short-term symptom-relief comparison (insufficient/contradictory); no separate estimate reported.
    1 study · 72 participants
    GRADE not reported

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs (Optimised) usual care

Gingivitis · Nursing home residents (mean age 78.3 to 86.0 years; more than 66% women; 62.1% to 87.3% with dental prostheses)
1 finding from 1 review

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · Children up to 13 years of age, undergoing cleft lip repair surgery

Perioperative infraorbital nerve block led to higher time to first analgesic requirement compared with infiltration of the incision (peri-incisional infiltration); GRADE not reported.

1 finding from 1 review

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Proportion developing new caries · Children and adolescents aged 16 years or less

Fluoride mouthrinse (any fluoride agent, concentration, volume,… showed no clear difference in proportion of children developing one or more new caries compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

Participants reporting swelling · People with one or more endodontically treated teeth and a periapical condition requiring retreatment
1 finding from 1 review
  • Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes
    first postoperative week
    Significantly higher number of participants reporting swelling in the root-end resection group than in the root canal retreatment group during the first postoperative week (Analysis 1.5); per-day totals not pooled.
    1 study
    GRADE not reported

Physical barriers (tongue protector + reinforced self-control instruction) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether physical barriers (tongue protector + reinforced self-control… changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Adverse effects · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

The review found no eligible studies for this question.

1 finding from 1 review

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Improvement of pre-existing accompanying symptoms other than pain · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Mucosal irritation / oral soft tissue allergic reaction (signs of sensitivity) · Children and adolescents aged 16 years or less
1 finding from 1 review

Antidepressants (trazodone 200 mg/day) vs placebo

Adverse effects: headache · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether antidepressants (trazodone 200 mg/day) changes adverse effects: headache compared with placebo (very low certainty).

1 finding from 1 review

Perioperative infraorbital nerve block vs Placebo (sham/placebo device)

Need for analgesic prescription for pain (supplemental analgesic requirements) · Children up to 13 years of age, undergoing cleft lip repair surgery

Perioperative infraorbital nerve block may leads to lower need for analgesic prescription for pain (supplemental analgesic… compared with placebo (sham block) (low certainty).

1 finding from 1 review

Dietary supplements (Catuama herbal compound) vs placebo

Weight gain · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (Catuama herbal compound) changes adverse effects: weight gain compared with placebo (very low certainty).

1 finding from 1 review

Intermediate restorative material (IRM) root-end filling vs Gutta-percha

Healing - 1 year or longer · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether intermediate restorative material (IRM) root-end filling changes healing - 1 year or longer compared with gutta-percha (very low certainty).

1 finding from 1 review

Amitriptyline vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Signs of acute toxicity during gel application (nausea, gagging, vomiting) · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review