What do systematic reviews say?

Intervention not reported

• Healthy eating interventions delivered in early childhood education and care settings for improving the diet of… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 101 participants
  Very low

Intervention not reported

• Healthy eating interventions delivered in early childhood education and care settings for improving the diet of… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 62 participants
  Very low

Sildenafil vs Placebo or no active treatment

Sildenafil citrate showed no clear difference in all‐cause mortality compared with placebo or no therapy (moderate certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 1.01 [0.8, 1.27]
  5 studies · 516 participants
  Moderate

Sildenafil vs IV nitroglycerin

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Sildenafil vs IV nitroglycerin

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Sildenafil vs IV nitroglycerin

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Sildenafil vs Placebo or no active treatment

Sildenafil citrate showed no clear difference in fetal mortality compared with placebo or no therapy (moderate certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 0.82 [0.6, 1.12]
  5 studies · 516 participants
  Moderate

Sildenafil vs Placebo or no active treatment

Sildenafil citrate showed no clear difference in neonatal mortality compared with placebo or no therapy (moderate certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 1.45 [0.9, 2.33]
  5 studies · 397 participants
  Moderate

Tadalafil vs Placebo or no active treatment

Tadalafil showed no clear difference in all‐cause mortality compared with placebo or no therapy (low certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 0.2 [0.02, 1.6]
  1 study · 87 participants
  Low

Tadalafil vs Placebo or no active treatment

Tadalafil showed no clear difference in fetal mortality compared with placebo or no therapy (low certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 0.11 [0.01, 1.96]
  1 study · 87 participants
  Low

Tadalafil vs Placebo or no active treatment

Tadalafil showed no clear difference in neonatal mortality compared with placebo or no therapy (low certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 0.89 [0.06, 13.7]
  1 study · 83 participants
  Low

Nitroglycerin vs Placebo or no active treatment

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Nitroglycerin vs Placebo or no active treatment

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Nitroglycerin vs Placebo or no active treatment

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in functional independence at 3 months (mRS 0 to 2) (primary outcome) compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 0.97 [0.82, 1.13]
  2 studies · 633 participants
  High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in successful reperfusion (mTICI 2b to 3) postprocedure compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 1.01 [0.95, 1.07]
  2 studies · 650 participants
  High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in all‐cause mortality within 3 months compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 1.01 [0.74, 1.37]
  2 studies · 633 participants
  High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in intracranial hemorrhage on imaging at 24 hours compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 1.03 [0.86, 1.24]
  2 studies · 645 participants
  High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in symptomatic intracranial hemorrhage at 24 hours compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 0.9 [0.49, 1.68]
  2 studies · 645 participants
  High

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Thrombo‐aspiration alone showed no clear difference in procedure‐related adverse events within 3 months compared with stent‐retrieval thrombectomy alone (high certainty).

• Different types of percutaneous endovascular interventions for acute ischemic stroke 2023 · Cochrane Headline outcomes only
  RR 0.98 [0.68, 1.41]
  2 studies · 651 participants
  High