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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,886 questions in 74 reviews · Skin
current versionsNo studies 542 · 28.7%Ungraded 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clarithromycin vs placebo The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea Interventions for pityriasis rosea (2019) · Cochrane | RR 1.13 [0.89, 1.44] | 1 study · 60 participants | Moderate |
Clarithromycin vs placebo Minor participant‐reported adverse events not requiring withdrawal of the treatment · pityriasis rosea Interventions for pityriasis rosea (2019) · Cochrane | no estimate extracted | NR | No studies |
Erythromycin vs placebo The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea Interventions for pityriasis rosea (2019) · Cochrane | no estimate extracted | NR | No studies |
Erythromycin vs placebo Serious adverse events, i.e. serious enough to require withdrawal of the treatment · pityriasis rosea Interventions for pityriasis rosea (2019) · Cochrane | no estimate extracted | 1 study · 34 participants | Moderate |
Erythromycin vs placebo The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea Interventions for pityriasis rosea (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Severe skin drug‐induced rash · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen… Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Long‐term sequelae · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen… Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Hospitalisation for drug‐induced skin reaction · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen… Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR SJS/TEN (Stevens‐Johnson syndrome/toxic epidermal necrolysis) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen… Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR AGEP (acute generalised exanthematous pustulosis) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen… Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR HSS (hypersensitivity) reaction including SJS/TEN (clinically diagnosed) (6 weeks clinical assessment) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen… Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane | RR 0.43 [0.28, 0.67] | 1 study · 1650 participants | Moderate |
Intervention NR HSS reaction including SJS/TEN (immunologically confirmed) (6 weeks clinical assessment) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen… Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane | RR 0.02 [0, 0.37] | 1 study · 1644 participants | Moderate |
Intervention NR Death · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen… Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane | no estimate extracted | NR | No studies |
Biotin vs placebo Change in severity · infantile seborrhoeic dermatitis (including cradle cap) Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane | no estimate extracted | 2 studies · 39 participants | Very low |
Biotin vs placebo Adverse events · infantile seborrhoeic dermatitis (including cradle cap) Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane | no estimate extracted | 2 studies · 39 participants | Ungraded |
Biotin vs placebo Quality of life · infantile seborrhoeic dermatitis (including cradle cap) Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane | no estimate extracted | NR | No studies |
Proprietary products vs placebo Change in severity · infantile seborrhoeic dermatitis (including cradle cap) Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane | no estimate extracted | 2 studies · 166 participants | Very low |
Proprietary products vs placebo Adverse events · infantile seborrhoeic dermatitis (including cradle cap) Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane | no estimate extracted | 2 studies · 166 participants | Very low |
Proprietary products vs placebo Quality of life · infantile seborrhoeic dermatitis (including cradle cap) Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane | no estimate extracted | NR | No studies |
Topical steroids vs comparator Change in severity · infantile seborrhoeic dermatitis (including cradle cap) Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane | no estimate extracted | 2 studies · 105 participants | Very low |
Topical steroids vs comparator Adverse events · infantile seborrhoeic dermatitis (including cradle cap) Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane | no estimate extracted | 2 studies · 105 participants | Very low |
Topical steroids vs comparator Quality of life · infantile seborrhoeic dermatitis (including cradle cap) Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane | no estimate extracted | NR | No studies |
Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion Percentage of participants clear or almost clear, i.e. obtaining PASI 100/90 and/or PGA of 0 or 1 in the short term · guttate psoriasis Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion Percentage of participants with adverse effects and severe adverse effects · guttate psoriasis Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion Number of relapses of guttate psoriasis or flares within a period of 6 months after the treatment has finished · guttate psoriasis Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion Percentage of participants achieving a PASI 75 or PGA of 1 or 2 · guttate psoriasis Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion Improvement in participant satisfaction measures and quality of life assessment measures Overall subjective score on 5 items (appearance of lesions, impairment of daily life, pruritus, burning, and pain) reported through figures · guttate psoriasis Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis (2019) · Cochrane | no estimate extracted | 1 study · 21 participants | Very low |
Penicillin vs no treatment Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Erythromycin vs no treatment Risk of having at least one relapse at long‐term · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Azithromycin vs vitamin C Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · chronic plaque psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Azithromycin vs vitamin C Proportion of participants with adverse events and severe adverse events · chronic plaque psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | 1 study · 50 participants | Ungraded |
Azithromycin vs vitamin C Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · chronic plaque psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Azithromycin vs vitamin C Proportion of participants achieving PASI 75 or PGA 1 to 2 · chronic plaque psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | RR 25.06 [1.6, 393.59] | 1 study · 50 participants | Very low |
Azithromycin vs vitamin C Risk of having at least one relapse at long‐term · chronic plaque psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Rifampicin vs placebo Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Rifampicin vs placebo Proportion of participants with adverse events and severe adverse events · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Rifampicin vs placebo Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Rifampicin vs placebo Proportion of participants achieving PASI 75 or PGA 1 to 2 · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Penicillin vs no treatment Proportion of participants with adverse events and severe adverse events · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | 1 study · 20 participants | Very low |
Rifampicin vs placebo Risk of having at least one relapse at long‐term · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Tonsillectomy vs no intervention Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · chronic plaque psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Tonsillectomy vs no intervention Proportion of participants with adverse events and severe adverse events · chronic plaque psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | RR 2.81 [0.12, 63.83] | 1 study · 29 participants | Very low |
Tonsillectomy vs no intervention Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · chronic plaque psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | RR 2.81 [0.12, 63.83] | 1 study · 29 participants | Very low |
Tonsillectomy vs no intervention Proportion of participants achieving PASI 75 or PGA 1 to 2 · chronic plaque psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | RR 6.56 [0.37, 116.7] | 1 study · 29 participants | Very low |
Tonsillectomy vs no intervention Risk of having at least one relapse at long‐term · chronic plaque psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Penicillin vs no treatment Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | RR 2 [0.68, 5.85] | 1 study · 20 participants | Very low |
Penicillin vs no treatment Proportion of participants achieving PASI 75 or PGA 1 to 2 · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Penicillin vs no treatment Risk of having at least one relapse at long‐term · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Erythromycin vs no treatment Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |
Erythromycin vs no treatment Proportion of participants with adverse events and severe adverse events · guttate psoriasis Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane | no estimate extracted | NR | No studies |