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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

1,886 questions in 74 reviews · Skin

current versions
No studies 542 · 28.7%Ungraded 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Clarithromycin vs placebo
The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea
Interventions for pityriasis rosea (2019) · Cochrane
RR 1.13 [0.89, 1.44]1 study · 60 participantsModerate
Clarithromycin vs placebo
Minor participant‐reported adverse events not requiring withdrawal of the treatment · pityriasis rosea
Interventions for pityriasis rosea (2019) · Cochrane
no estimate extractedNRNo studies
Erythromycin vs placebo
The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea
Interventions for pityriasis rosea (2019) · Cochrane
no estimate extractedNRNo studies
Erythromycin vs placebo
Serious adverse events, i.e. serious enough to require withdrawal of the treatment · pityriasis rosea
Interventions for pityriasis rosea (2019) · Cochrane
no estimate extracted1 study · 34 participantsModerate
Erythromycin vs placebo
The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea
Interventions for pityriasis rosea (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Severe skin drug‐induced rash · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen…
Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Long‐term sequelae · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen…
Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Hospitalisation for drug‐induced skin reaction · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen…
Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
SJS/TEN (Stevens‐Johnson syndrome/toxic epidermal necrolysis) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen…
Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
AGEP (acute generalised exanthematous pustulosis) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen…
Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane
no estimate extractedNRNo studies
Intervention NR
HSS (hypersensitivity) reaction including SJS/TEN (clinically diagnosed) (6 weeks clinical assessment) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen…
Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane
RR 0.43 [0.28, 0.67]1 study · 1650 participantsModerate
Intervention NR
HSS reaction including SJS/TEN (immunologically confirmed) (6 weeks clinical assessment) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen…
Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane
RR 0.02 [0, 0.37]1 study · 1644 participantsModerate
Intervention NR
Death · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen…
Genetic testing for prevention of severe drug‐induced skin rash (2019) · Cochrane
no estimate extractedNRNo studies
Biotin vs placebo
Change in severity · infantile seborrhoeic dermatitis (including cradle cap)
Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane
no estimate extracted2 studies · 39 participantsVery low
Biotin vs placebo
Adverse events · infantile seborrhoeic dermatitis (including cradle cap)
Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane
no estimate extracted2 studies · 39 participantsUngraded
Biotin vs placebo
Quality of life · infantile seborrhoeic dermatitis (including cradle cap)
Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane
no estimate extractedNRNo studies
Proprietary products vs placebo
Change in severity · infantile seborrhoeic dermatitis (including cradle cap)
Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane
no estimate extracted2 studies · 166 participantsVery low
Proprietary products vs placebo
Adverse events · infantile seborrhoeic dermatitis (including cradle cap)
Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane
no estimate extracted2 studies · 166 participantsVery low
Proprietary products vs placebo
Quality of life · infantile seborrhoeic dermatitis (including cradle cap)
Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane
no estimate extractedNRNo studies
Topical steroids vs comparator
Change in severity · infantile seborrhoeic dermatitis (including cradle cap)
Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane
no estimate extracted2 studies · 105 participantsVery low
Topical steroids vs comparator
Adverse events · infantile seborrhoeic dermatitis (including cradle cap)
Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane
no estimate extracted2 studies · 105 participantsVery low
Topical steroids vs comparator
Quality of life · infantile seborrhoeic dermatitis (including cradle cap)
Interventions for infantile seborrhoeic dermatitis (including cradle cap) (2019) · Cochrane
no estimate extractedNRNo studies
Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion
Percentage of participants clear or almost clear, i.e. obtaining PASI 100/90 and/or PGA of 0 or 1 in the short term · guttate psoriasis
Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion
Percentage of participants with adverse effects and severe adverse effects · guttate psoriasis
Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion
Number of relapses of guttate psoriasis or flares within a period of 6 months after the treatment has finished · guttate psoriasis
Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion
Percentage of participants achieving a PASI 75 or PGA of 1 or 2 · guttate psoriasis
Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion
Improvement in participant satisfaction measures and quality of life assessment measures Overall subjective score on 5 items (appearance of lesions, impairment of daily life, pruritus, burning, and pain) reported through figures · guttate psoriasis
Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis (2019) · Cochrane
no estimate extracted1 study · 21 participantsVery low
Penicillin vs no treatment
Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Erythromycin vs no treatment
Risk of having at least one relapse at long‐term · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Azithromycin vs vitamin C
Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · chronic plaque psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Azithromycin vs vitamin C
Proportion of participants with adverse events and severe adverse events · chronic plaque psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extracted1 study · 50 participantsUngraded
Azithromycin vs vitamin C
Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · chronic plaque psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Azithromycin vs vitamin C
Proportion of participants achieving PASI 75 or PGA 1 to 2 · chronic plaque psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
RR 25.06 [1.6, 393.59]1 study · 50 participantsVery low
Azithromycin vs vitamin C
Risk of having at least one relapse at long‐term · chronic plaque psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Rifampicin vs placebo
Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Rifampicin vs placebo
Proportion of participants with adverse events and severe adverse events · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Rifampicin vs placebo
Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Rifampicin vs placebo
Proportion of participants achieving PASI 75 or PGA 1 to 2 · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Penicillin vs no treatment
Proportion of participants with adverse events and severe adverse events · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extracted1 study · 20 participantsVery low
Rifampicin vs placebo
Risk of having at least one relapse at long‐term · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Tonsillectomy vs no intervention
Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · chronic plaque psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Tonsillectomy vs no intervention
Proportion of participants with adverse events and severe adverse events · chronic plaque psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
RR 2.81 [0.12, 63.83]1 study · 29 participantsVery low
Tonsillectomy vs no intervention
Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · chronic plaque psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
RR 2.81 [0.12, 63.83]1 study · 29 participantsVery low
Tonsillectomy vs no intervention
Proportion of participants achieving PASI 75 or PGA 1 to 2 · chronic plaque psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
RR 6.56 [0.37, 116.7]1 study · 29 participantsVery low
Tonsillectomy vs no intervention
Risk of having at least one relapse at long‐term · chronic plaque psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Penicillin vs no treatment
Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
RR 2 [0.68, 5.85]1 study · 20 participantsVery low
Penicillin vs no treatment
Proportion of participants achieving PASI 75 or PGA 1 to 2 · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Penicillin vs no treatment
Risk of having at least one relapse at long‐term · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Erythromycin vs no treatment
Time‐to‐resolution: achieving PASI 90 to 100 or PGA 0 to 1 · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies
Erythromycin vs no treatment
Proportion of participants with adverse events and severe adverse events · guttate psoriasis
Antistreptococcal interventions for guttate and chronic plaque psoriasis (2019) · Cochrane
no estimate extractedNRNo studies