What do systematic reviews say?

Intraligamental injection local anaesthetic vs no treatment

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  The studies did not report on patient or child satisfaction
  0 studies
  No studies found

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  6 hours postdosing · Ibuprofen 400 mg vs paracetamol 1000 mg
  RR 1.47 [1.28, 1.69]
  5 studies · 646 participants
  High

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Combined paracetamol plus ibuprofen in a single tablet (e.g.… showed no clear difference in proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  2 hours postdosing · Paracetamol 1000 mg/ibuprofen 400 mg vs paracetamol 1000 mg or ibuprofen 400 mg
  RR 1.29 [0.91, 1.85]
  1 study · 170 participants
  Moderate

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  Study period (immediate postoperative)
  The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
  2 studies
  GRADE not reported

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Combined paracetamol plus ibuprofen in a single tablet (e.g.… probably leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (moderate certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  6 hours postdosing · Paracetamol 1000 mg/ibuprofen 400 mg vs paracetamol 1000 mg or ibuprofen 400 mg
  RR 1.77 [1.32, 2.39]
  1 study · 170 participants
  Moderate

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  2 hours postdosing · Ibuprofen 400 mg vs paracetamol 1000 mg
  RR 1.30 [1.09, 1.55]
  5 studies · 645 participants
  High

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher patients not using rescue medication at 6 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  6 hours postdosing · Ibuprofen 400 mg vs paracetamol 1000 mg
  RR 1.50 [1.25, 1.79]
  4 studies · 542 participants
  High

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) led to higher patients using rescue medication at 8 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg…; GRADE not reported.

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  8 hours postdosing
  RR 2.02 [1.57, 2.60]
  2 studies
  GRADE not reported

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Combined paracetamol plus ibuprofen in a single tablet (e.g.… leads to higher patients not using rescue medication at 8 hours compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (high certainty).

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  8 hours postdosing · Paracetamol 1000/500 mg/ibuprofen 400/200 mg vs single constituent drugs
  RR 1.60 [1.36, 1.88]
  2 studies · 467 participants
  High

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  Study period (immediate postoperative)
  The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
  7 studies
  GRADE not reported

Hypnosis vs Inhalation sedation with nitrous oxide and oxygen

The review found no eligible studies for this question.

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  Completion of treatment (yes/no) was a protocol-planned primary outcome but was not reported by the included study for this comparison (Braithwaite 2005); one participant in the sedation arm was withdrawn during…
  Studies not reported
  No studies found

Hypnosis vs Inhalation sedation with nitrous oxide and oxygen

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  Hypnosis did not provide sufficient anxiety control during tooth extraction, and overall response to treatment remained statistically lower than response to inhalation sedation with nitrous oxide and oxygen (i.e. the…
  1 study · 10 participants
  GRADE not reported

Hypnosis vs No hypnosis (no hypnotic intervention)

The review found no eligible studies for this question.

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  Completion of treatment was a protocol-planned primary outcome but was not reported as an outcome by any of the three included studies; statistical analysis and meta-analysis were not possible due to the insufficient…
  Studies not reported
  No studies found

Hypnosis vs No hypnosis (no hypnotic intervention)

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  With regard to oxygen saturation and pulse rate, only pulse rate was significantly lower in the hypnosis group (P = 0.005); oxygen saturation did not differ significantly. (Gokli 1994; cross-over, 29 children.)
  1 study · 29 participants
  GRADE not reported

Hypnosis vs No hypnosis (no hypnotic intervention)

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  None of the studies mentioned any adverse effects regarding hypnosis. (Gokli 1994; Trakyali 2008.)
  2 studies · 59 participants
  GRADE not reported

Hypnosis vs Inhalation sedation with nitrous oxide and oxygen

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  The majority of patients preferred inhalation sedation over hypnosis. (Braithwaite 2005; 10 patients.)
  1 study · 10 participants
  GRADE not reported

Hypnosis vs Inhalation sedation with nitrous oxide and oxygen

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  No significant difference in total treatment time between inhalation sedation and hypnorelaxation; hypnorelaxation demanded little additional time to complete care. (Braithwaite 2005.)
  1 study · 10 participants
  GRADE not reported

Hypnosis vs No hypnosis (no hypnotic intervention)

The review found no eligible studies for this question.

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  Difference in post-operative anxiety was a protocol-planned outcome but was not measured or reported by any included study (no post-operative anxiety scale was reported).
  Studies not reported
  No studies found

Hypnosis vs Inhalation sedation with nitrous oxide and oxygen

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  None of the studies mentioned any adverse effects regarding hypnosis. (Braithwaite 2005.)
  1 study · 10 participants
  GRADE not reported

Hypnosis combined with a sedative agent vs Sedation alone (sedative agent only)

The review found no eligible studies for this question.

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  No randomised or quasi-randomised trials comparing hypnosis combined with sedation versus sedation alone met the inclusion criteria; this planned comparison had no eligible studies.
  0 studies
  No studies found