Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

483 questions · 519 findings · 42 reviews · Headline outcomes only

No studies found 136 · 26.2%GRADE not reported 9 · 1.7%Very low 136 · 26.2%Low 150 · 28.9%Moderate 68 · 13.1%High 20 · 3.9%

CONTINGENCY MANAGEMENT vs usual care

Drug (non‐alcohol) use Number with stimulant‐positive urine test · people with both severe mental illness and substance misuse

Contingency management showed no clear difference in substance use: Drug (non‐alcohol) Number with stimulant‐positive… compared with standard care (low certainty).

1 finding from 1 review

INTEGRATED MODELS OF CARE vs usual care

Substance use: any change ‐ Alcohol use (not in remission) · people with both severe mental illness and substance misuse

Integrated models of care showed no clear difference in substance use: any change ‐ Alcohol use (not in remission) compared with standard care (low certainty).

1 finding from 1 review