Serious adverse events · people with bronchiectasis
14 days on/off antibiotic regimen showed no clear difference in serious adverse events compared with 14 days on/off placebo regimen (high certainty).
1 finding from 1 review
OR 0.92 [0.63, 1.33]
Studies not reported
High
Antibiotic resistance · people with bronchiectasis
14 days on/off antibiotic regimen leads to higher antibiotic resistance compared with 14 days on/off placebo regimen (high certainty).
1 finding from 1 review
OR 2.14 [1.36, 3.35]
Studies not reported
High
Frequency of hospital admissions for pulmonary exacerbations ‐ not measured · people with bronchiectasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life · people with bronchiectasis
2 findings from 1 review
no estimate extracted
Studies not reported
High
no estimate extracted
Studies not reported
Moderate
Exacerbation frequency · people with bronchiectasis
28 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off placebo regimen (high certainty).
2 findings from 1 review
RR 0.92 [0.82, 1.02]
Studies not reported
High
no estimate extracted
Studies not reported
Low
Recurrent seizure at 6 months · children with febrile seizures
Intermittent oral or rectal diazepam probably leads to lower recurrent seizure at 6 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Recurrent seizure at 18 months · children with febrile seizures
Continuous phenobarbital showed no clear difference in recurrent seizure at 18 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Recurrent seizure at 12 months · children with febrile seizures
It is very uncertain whether intermittent oral levetiracetam changes recurrent seizures at 12 months compared with placebo (any antipyretics) (very low certainty).
1 finding from 1 review
Recurrent seizure at 18 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrent seizure at 24 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrent seizure at 36 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrent seizure at 48 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrent seizure at 60 months or greater · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrent seizure at 24 months · children with febrile seizures
Continuous phenobarbital probably leads to lower recurrent seizure at 24 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Recurrent seizure at 36 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrent seizure at 48 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrent seizure at 60 months or greater · children with febrile seizures
It is very uncertain whether continuous phenobarbital changes recurrent seizure at 60 months or greater compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Recurrent seizure at 6 months · children with febrile seizures
It is very uncertain whether intermittent phenobarbital changes recurrent seizure at 6 months compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Recurrent seizure at 12 months · children with febrile seizures
Intermittent phenobarbital showed no clear difference in recurrent seizure at 12 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Recurrent seizure at 18 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found