Heliox vs oxygen 30%
Proportion of children intubated · children with croup
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
393 questions · 411 findings · 111 reviews
No studies found 51 · 12.4%GRADE not reported 40 · 9.7%Very low 86 · 20.9%Low 121 · 29.4%Moderate 84 · 20.4%High 29 · 7.1%
Heliox vs oxygen 30%
Duration of intubation · children with croup
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Heliox vs oxygen 30%
Proportion of children re‐presenting for medical care for ongoing croup symptoms (return to care) · children with croup
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Heliox vs oxygen 30%
Adverse events · children with croup
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors
Function: mean change in pain with movement from baseline on4‐point (0 to 3, 0 best function) Likert scale · acute gout
1 finding from 1 review
- no estimate extractedStudies not reportedLow
Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors
Global assessment of treatment success · acute gout
1 finding from 1 review
- no estimate extractedStudies not reportedModerate
Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors
Health‐related quality of life (mental) · acute gout
1 finding from 1 review
- no estimate extractedStudies not reportedLow
Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors
Withdrawals due to adverse events · acute gout
Non‐selective NSAIDs probably leads to higher withdrawals due to adverse events compared with selective cyclo‐oxygenase‐2 inhibitors (moderate certainty).
1 finding from 1 review
- RR 2.34 [1.33, 4.14]Studies not reportedModerate
Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors
Total adverse events · acute gout
Non‐selective NSAIDs probably leads to higher total adverse events compared with selective cyclo‐oxygenase‐2 inhibitors (moderate certainty).
1 finding from 1 review
- RR 1.94 [1.36, 2.78]Studies not reportedModerate
Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · acute gout
1 finding from 1 review
- no estimate extractedStudies not reportedModerate
Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors
Swelling (mean) · acute gout
1 finding from 1 review
- no estimate extractedStudies not reportedModerate
HFNC vs standard oxygen therapy
Treatment failure (escalation of respiratory therapy to NIV, NIPPV or invasive ventilation) Measured up to 28 days · adults in the ICU, requiring respiratory support
HFNC may leads to lower treatment failure (escalation of respiratory therapy to NIV, NIPPV… compared with standard oxygen therapy (low certainty).
1 finding from 1 review
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyRR 0.62 [0.45, 0.86]15 studies · 3044 participantsLow
HFNC vs standard oxygen therapy
In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with standard oxygen therapy (moderate certainty).
1 finding from 1 review
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyRR 0.96 [0.82, 1.11]11 studies · 2673 participantsModerate
HFNC vs standard oxygen therapy
Adverse events Respiratory infection (pneumonia) Nasal mucosa or skin trauma · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in adverse events Respiratory infection (pneumonia) Nasal mucosa or… compared with standard oxygen therapy (moderate certainty).
1 finding from 1 review
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyRR 0.72 [0.48, 1.09]4 studies · 1057 participantsModerate
HFNC vs standard oxygen therapy
Duration of ICU stay · adults in the ICU, requiring respiratory support
1 finding from 1 review
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyno estimate extracted7 studies · 1014 participantsLow
HFNC vs standard oxygen therapy
Respiratory effects: PaO2/FiO2 ratio up to 24 hours after initiation of therapy · adults in the ICU, requiring respiratory support
1 finding from 1 review
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyno estimate extracted5 studies · 600 participantsVery low
HFNC vs standard oxygen therapy
Comfort · adults in the ICU, requiring respiratory support
2 findings from 1 review
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyno estimate extracted4 studies · 662 participantsVery low
- High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 445 participantsVery low
Continuous positive airway pressure (CPAP) vs supplemental oxygen
Treatment failure (death or use of additional ventilatory support) · preterm infants with respiratory distress for initial respiratory support
It is very uncertain whether CPAP changes treatment failure (death or use of additional ventilatory support) compared with supplemental oxygen (very low certainty).
1 finding from 1 review
- Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants 2020 · Cochrane Headline outcomes onlyRR 0.64 [0.5, 0.82]5 studies · 322 participantsVery low
Continuous positive airway pressure (CPAP) vs supplemental oxygen
Use of assisted ventilation · preterm infants with respiratory distress for initial respiratory support
It is very uncertain whether CPAP changes use of assisted ventilation compared with supplemental oxygen (very low certainty).
1 finding from 1 review
- Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants 2020 · Cochrane Headline outcomes onlyRR 0.72 [0.54, 0.96]3 studies · 233 participantsVery low
Continuous positive airway pressure (CPAP) vs supplemental oxygen
All‐cause mortality · preterm infants with respiratory distress for initial respiratory support
CPAP probably leads to lower mortality compared with supplemental oxygen (moderate certainty).
1 finding from 1 review
- Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants 2020 · Cochrane Headline outcomes onlyRR 0.53 [0.34, 0.83]5 studies · 322 participantsModerate