Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,156 questions · 1,179 findings · 198 reviews · Headline outcomes only

No studies found 250 · 21.2%GRADE not reported 43 · 3.6%Very low 236 · 20%Low 395 · 33.5%Moderate 208 · 17.6%High 47 · 4%

Combined trabeculotomy with trabeculectomy vs trabeculotomy

Proportion of participants with IOP≤ 21 mmHg, with or without ocular hypotensive medications 1 year · children at or before five years of age with primary congenital glaucoma

It is very uncertain whether combined trabeculotomy with trabeculectomy changes surgical success: proportion with postoperative IOP ≤ 21 mmHg with… compared with trabeculotomy (very low certainty).

1 finding from 1 review

Viscotrabeculotomy vs conventional trabeculotomy

Proportion with postoperative IOP ≤ 21 mmHg (surgical success) with or without glaucoma medications 6 months after surgery · children at or before five years of age with primary congenital glaucoma

It is very uncertain whether viscotrabeculotomy changes proportion with postoperative IOP ≤ 21 mmHg (surgical success) with… compared with conventional trabeculotomy (very low certainty).

1 finding from 1 review

Microcatheter‐assisted trabeculotomy vs conventional trabeculotomy

Proportion of participants with IOP≤ 21 mmHg, with or without ocular hypotensive medications 1 year · children at or before five years of age with primary congenital glaucoma

Microcatheter‐assisted trabeculotomy probably leads to higher proportion with postoperative IOP ≤ 21 mmHg (surgical success) with… compared with conventional trabeculotomy (moderate certainty).

1 finding from 1 review

Intervention not reported

Preoperative anxiety (VAS) VAS (0 to 100 mm) measured approximately 50 to 120 minutes after premedication 0: no anxiety 100: maximum anxiety possible · patents undergoing elective surgery
1 finding from 1 review

Intervention not reported

Preoperative anxiety (STAI) STAI (20 to 80) measured approximately 120 minutes after premedication 20: no anxiety 80: maximum anxiety possible · patents undergoing elective surgery
1 finding from 1 review

Intervention not reported

Preoperative anxiety (6‐item STAI) STAI 6‐item (6 to 24) measured approximately 90 minutes after premedication 6: no anxiety 24: maximum anxiety possible · patents undergoing elective surgery
1 finding from 1 review

Intervention not reported

Preoperative anxiety (VAS) VAS (0 to 100 mm) measured approximately 90 minutes after premedication 0: no anxiety 100: maximum anxiety possible · patients undergoing elective surgery
1 finding from 1 review

Intervention not reported

Preoperative anxiety (6‐item STAI) STAI 6‐item (6 to 24) measured approximately 90 minutes after premedication 6: no anxiety 24: maximum anxiety possible · patients undergoing elective surgery
1 finding from 1 review

Calcineurin inhibitor vs IV cyclophosphamide

Discontinuation of medication due to adverse events · idiopathic steroid‐resistant nephrotic syndrome in children

Calcineurin inhibitor probably leads to lower adverse events: medications ceased due to adverse events compared with IV cyclophosphamide (moderate certainty).

1 finding from 1 review

Exercise vs NSAIDs

Use of rescue medication · young women with suspected primary dysmenorrhoea

It is very uncertain whether exercise changes use of rescue analgesic medication assessed by: number of women who… compared with non‐steroidal anti‐inflammatory drugs (NSAIDs) (very low certainty).

1 finding from 1 review

Exercise vs no treatment

Use of rescue analgesic medication ‐ not reported · young women with suspected primary dysmenorrhoea

The review found no eligible studies for this question.

1 finding from 1 review