Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,281 questions · 1,307 findings · 212 reviews

No studies found 256 · 19.6%GRADE not reported 125 · 9.6%Very low 266 · 20.4%Low 403 · 30.8%Moderate 208 · 15.9%High 49 · 3.7%

Combined trabeculotomy with trabeculectomy vs trabeculotomy

Proportion of participants with IOP≤ 21 mmHg, with or without ocular hypotensive medications 1 year · children at or before five years of age with primary congenital glaucoma

It is very uncertain whether combined trabeculotomy with trabeculectomy changes surgical success: proportion with postoperative IOP ≤ 21 mmHg with… compared with trabeculotomy (very low certainty).

1 finding from 1 review

Viscotrabeculotomy vs conventional trabeculotomy

Proportion with postoperative IOP ≤ 21 mmHg (surgical success) with or without glaucoma medications 6 months after surgery · children at or before five years of age with primary congenital glaucoma

It is very uncertain whether viscotrabeculotomy changes proportion with postoperative IOP ≤ 21 mmHg (surgical success) with… compared with conventional trabeculotomy (very low certainty).

1 finding from 1 review

Microcatheter‐assisted trabeculotomy vs conventional trabeculotomy

Proportion of participants with IOP≤ 21 mmHg, with or without ocular hypotensive medications 1 year · children at or before five years of age with primary congenital glaucoma

Microcatheter‐assisted trabeculotomy probably leads to higher proportion with postoperative IOP ≤ 21 mmHg (surgical success) with… compared with conventional trabeculotomy (moderate certainty).

1 finding from 1 review

Intervention not reported

Preoperative anxiety (VAS) VAS (0 to 100 mm) measured approximately 50 to 120 minutes after premedication 0: no anxiety 100: maximum anxiety possible · patents undergoing elective surgery
1 finding from 1 review

Intervention not reported

Preoperative anxiety (STAI) STAI (20 to 80) measured approximately 120 minutes after premedication 20: no anxiety 80: maximum anxiety possible · patents undergoing elective surgery
1 finding from 1 review

Intervention not reported

Preoperative anxiety (6‐item STAI) STAI 6‐item (6 to 24) measured approximately 90 minutes after premedication 6: no anxiety 24: maximum anxiety possible · patents undergoing elective surgery
1 finding from 1 review

Intervention not reported

Preoperative anxiety (VAS) VAS (0 to 100 mm) measured approximately 90 minutes after premedication 0: no anxiety 100: maximum anxiety possible · patients undergoing elective surgery
1 finding from 1 review

Intervention not reported

Preoperative anxiety (6‐item STAI) STAI 6‐item (6 to 24) measured approximately 90 minutes after premedication 6: no anxiety 24: maximum anxiety possible · patients undergoing elective surgery
1 finding from 1 review

Calcineurin inhibitor vs IV cyclophosphamide

Discontinuation of medication due to adverse events · idiopathic steroid‐resistant nephrotic syndrome in children

Calcineurin inhibitor probably leads to lower adverse events: medications ceased due to adverse events compared with IV cyclophosphamide (moderate certainty).

1 finding from 1 review

Exercise vs NSAIDs

Use of rescue medication · young women with suspected primary dysmenorrhoea

It is very uncertain whether exercise changes use of rescue analgesic medication assessed by: number of women who… compared with non‐steroidal anti‐inflammatory drugs (NSAIDs) (very low certainty).

1 finding from 1 review