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Evidence found and GRADE certainty

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

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No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Prevalence of methamphetamine use (1 to 6 months post intervention) (RR < 1 denotes lower prevalence compared to control) · adult patients with harmful or hazardous alcohol or substance use

Lay health worker‐led interventions for adult patients with harmful… showed no clear difference in prevalence of methamphetamine use (1 to 6 months post intervention)… compared with enhanced usual care (low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Service utilisation ‐ unplanned hospitalisations (1 to 6 months post intervention) (RR < 1 denotes lower risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes service utilisation ‐ unplanned hospitalisations (1 to 6 months post… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Adverse events ‐ death in past 12 months (RR > 1 denotes higher risk of death) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether lay health worker‐led interventions for adult patients with harmful… changes adverse events ‐ deaths (RR < 1 denotes lower risk) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Cannabis use · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of cannabis use (1 to 6 months post intervention) (RR < 1… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Adverse events RR < 1 indicates lower risk of adverse events · adults with common mental disorders

Lay health worker‐led psychological interventions may leads to lower adverse events RR < 1 indicates lower risk of adverse events compared with usual care (low certainty).

1 finding from 1 review

Primary‐level worker‐led collaborative care vs usual care

Prevalence of CMD ‐ intermediate term (1 to 6 months post intervention) Diagnosis defined by presence of ICD‐10 diagnosis on CIS‐Rg; prevalence defined by [Total number ‐ number recovered (recovery defined by HDRS < 8)]c (RR < 1 denotes lower prev... · adults with common mental disorders

Primary‐level worker‐led collaborative care showed no clear difference in prevalence of CMD ‐ intermediate term (1 to 6 months post… compared with usual care (low certainty).

1 finding from 1 review