Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

317 questions · 341 findings · 38 reviews · Vascular

No studies found 55 · 16.1%GRADE not reported 32 · 9.4%Very low 58 · 17%Low 117 · 34.3%Moderate 57 · 16.7%High 22 · 6.5%

Low molecular weight heparin vs vitamin K antagonist (VKA)

Major bleeding · patients with symptomatic VTE requiring long term treatment (3 months) for symptomatic VTE

LMWH may leads to lower incidence of major bleeding (treatment duration 3 months) compared with VKA (low certainty).

1 finding from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Mortality (treatment duration 3 months) · patients with symptomatic VTE requiring long term treatment (3 months) for symptomatic VTE

LMWH showed no clear difference in mortality (treatment duration 3 months) compared with VKA (moderate certainty).

1 finding from 1 review

Intervention not reported

Heparin‐induced thrombocytopenia (HIT) · people undergoing surgical procedures and treated with UFH or LMWH for prophylaxis of thrombotic events lasting at least 5 days

The intervention may leads to lower heparin‐induced thrombocytopenia (HIT) (low certainty).

1 finding from 1 review

Intervention not reported

HIT in people undergoing major surgical procedures · people undergoing surgical procedures and treated with UFH or LMWH for prophylaxis of thrombotic events lasting at least 5 days

The intervention may leads to lower HIT in people undergoing major surgical procedures (low certainty).

1 finding from 1 review

Intervention not reported

HIT complicated by venous thromboembolism · people undergoing surgical procedures and treated with UFH or LMWH for prophylaxis of thrombotic events lasting at least 5 days

The intervention may leads to lower HIT complicated by venous thromboembolism (low certainty).

1 finding from 1 review

Subintimal angioplasty with stenting vs remote endarterectomy

Clinical improvement: Rutherford classification improvement Rutherford classification · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in clinical improvement: Rutherford classification improvement… compared with remote endarterectomy (low certainty).

1 finding from 1 review

OUTBACK re‐entry catheter vs manual re‐entry

months' patency rate · 52 people with TASC‐II D superficial femoral artery chronic total occlusions

OUTBACK re‐entry catheter showed no clear difference in months' patency rate compared with manual re‐entry (low certainty).

2 findings from 1 review

OUTBACK re‐entry catheter vs manual re‐entry

Primary patency ( · 52 people with TASC‐II D superficial femoral artery chronic total occlusions
2 findings from 1 review

Subintimal angioplasty with stenting vs remote endarterectomy

Clinical improvement: ABI improvement Significant postexercise ABI improvement · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in clinical improvement: ABI improvement Significant postexercise ABI… compared with remote endarterectomy (low certainty).

1 finding from 1 review

Subintimal angioplasty with stenting vs remote endarterectomy

months' patency rate · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in months' patency rate compared with remote endarterectomy (low certainty).

3 findings from 1 review