Findings

What do systematic reviews say?

2,327 questions · 2,494 findings · 87 reviews · Oral Health

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No studies found 450 · 18%GRADE not reported 1,487 · 59.6%Very low 385 · 15.4%Low 121 · 4.9%Moderate 50 · 2%High 1 · 0%

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Patient quality of life · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)

The review found no eligible studies for this question.

1 finding from 1 review

Orthodontics for treating temporomandibular joint (TMJ) disorders 2010 · Cochrane All outcomes
At least 6 months after the intervention
no estimate extracted
0 studies
No studies found

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Adverse effects on oral health · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)

The review found no eligible studies for this question.

1 finding from 1 review

Orthodontics for treating temporomandibular joint (TMJ) disorders 2010 · Cochrane All outcomes
At least 6 months after the intervention
no estimate extracted
0 studies
No studies found

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Limitation of movement · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)

The review found no eligible studies for this question.

1 finding from 1 review

Orthodontics for treating temporomandibular joint (TMJ) disorders 2010 · Cochrane All outcomes
At least 6 months after the intervention
no estimate extracted
0 studies
No studies found

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Development of TMD (onset/incidence of signs and symptoms) · People without TMD at baseline undergoing orthodontic treatment (TMD clinically absent at baseline); no age restriction provided follow-up…

The review found no eligible studies for this question.

1 finding from 1 review

Orthodontics for treating temporomandibular joint (TMJ) disorders 2010 · Cochrane All outcomes
Follow-up period extended into adulthood
no estimate extracted
0 studies
No studies found

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Overall symptoms, pain and headache (relief from symptoms assessed by global measures) · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)

The review found no eligible studies for this question.

1 finding from 1 review

Orthodontics for treating temporomandibular joint (TMJ) disorders 2010 · Cochrane All outcomes
At least 6 months after the intervention
no estimate extracted
0 studies
No studies found

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

Sugar intake frequency between meals (mean number of intakes per day) · Adults with frequent sugar intake harbouring Streptococcus mutans and Streptococcus sobrinus in saliva (14 dental technical students and 6…

1 finding from 1 review

One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes
Follow-up at 3, 6 and 12 weeks
Table 5, mean (SD) intakes/day between meals: intervention 6.7 (1.9) baseline, 0.8 (1.0) at 3 weeks, 0.9 (1.0) at 6 weeks, 5.6 (3.0) at 12 weeks; control 5.3 (2.3), 5.2 (2.9), 4.6 (3.5), 4.7 (1.5). Significant…
1 study · 20 participants
GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

Sugar intake frequency at main meals (mean number of intakes per day) · Adults with frequent sugar intake harbouring Streptococcus mutans and Streptococcus sobrinus in saliva (14 dental technical students and 6…

1 finding from 1 review

One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes
Follow-up at 3, 6 and 12 weeks
Table 5, mean (SD) intakes/day at main meals: intervention 2.8 (0.5) baseline, 0.7 (0.7) at 3 weeks, 0.8 (0.9) at 6 weeks, 2.3 (0.8) at 12 weeks; control 1.9 (1.1), 1.9 (1.2), 1.9 (1.1), 2.0 (0.9). Significant…
1 study · 20 participants
GRADE not reported

One-to-one advice on sugar restriction: detailed information on the sugar content of foods, with instruction to refrain from sugar-containing foods between meals and to reduce sugar in main meals (6-week sugar restriction) vs No advice on sugar restriction

Total sugar intake frequency (mean number of intakes per day) · Adults with frequent sugar intake harbouring Streptococcus mutans and Streptococcus sobrinus in saliva (14 dental technical students and 6…

1 finding from 1 review

One‐to‐one dietary interventions undertaken in a dental setting to change dietary behaviour 2012 · Cochrane All outcomes
Follow-up at 3, 6 and 12 weeks
Table 5, total mean (SD) intakes/day: intervention 9.5 (1.9) baseline, 1.6 (1.4) at 3 weeks, 1.8 (1.5) at 6 weeks, 7.8 (3.5) at 12 weeks; control 7.2 (2.6), 7.1 (3.7), 6.5 (4.2), 6.7 (2.2). Significant reduction versus…
1 study · 20 participants
GRADE not reported

Professional oral care vs Usual oral care

Adverse effects of interventions · Residents of nursing homes and other long-term care facilities

1 finding from 1 review

Oral care measures for preventing nursing home‐acquired pneumonia 2022 · Cochrane All outcomes
Measured in only 1 study (834 participants), which reported no serious events and 64 non-serious events, the most common of which were oral cavity disturbances (not defined) and dental staining.
1 study · 834 participants
GRADE not reported

Supportive periodontal therapy (SPT) including mechanical debridement vs Monitoring only, or alternative interventions that do not include mechanical debridement

Outcome not reported · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

The review found no eligible studies for this question.

1 finding from 1 review

Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

Costs (direct costs of interventions) · Adults and adolescents in any age group with restorations in the permanent dentition and children with restorations in the primary dentition

The review found no eligible studies for this question.

1 finding from 1 review

Antibacterial agents in composite restorations for the prevention of dental caries 2013 · Cochrane All outcomes
No studies were included in this review, as we were unable to find any trials directly comparing antibacterial containing composites to other active interventions or controls.
0 studies
No studies found

DHAT-delivered dental care vs Dentist-delivered dental care

Technical performance / deficient restorations (DHATs vs dentists) · Alaska Native dental patients (children aged 6-17 and adults) and their caregivers

DHATs had a lower amalgam restoration deficiency rate than dentists (12% vs 22%; certainty not graded).

3 findings from 1 review

Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
Cross-sectional (DHATs practising ~9 months to several years) · Alaska Native communities (Alaska Dental Health Aide Therapist program) · Amalgam restorations
Deficient restorations (%), DHAT vs dentist 12 vs 22 (DHAT vs dentist)
2 studies
GRADE not reported
Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
Cross-sectional (DHATs practising ~9 months to several years) · Alaska Native communities (Alaska Dental Health Aide Therapist program) · Composite restorations
Deficient restorations (%), DHAT vs dentist 15 vs 12 (DHAT vs dentist)
2 studies
GRADE not reported
Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
Cross-sectional (DHATs practising ~9 months to several years) · Alaska Native communities (Alaska Dental Health Aide Therapist program) · Stainless steel crowns
Deficient placements (%), DHAT vs dentist 3 vs 9 (DHAT vs dentist)
2 studies
GRADE not reported

Intervention not reported

Technical performance / deficient preparations (DHATs)

1 finding from 1 review

Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
Composite preparations
Deficient preparations (%) 0
2 studies
GRADE not reported

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Recurrence · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
Recurrence: outcome not reported in a usable way (Mehanna 2017: nodal recurrence 3 vs 1; distant metastases 21 vs 23).
1 study
GRADE not reported

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Total mortality · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)

PET-CT following chemoradiotherapy (neck dissection only if… showed no clear difference in total mortality compared with planned neck dissection before or after chemoradiotherapy (moderate certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 0.92 [0.65, 1.31]
1 study · 564 participants
Moderate

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)

PET-CT following chemoradiotherapy (neck dissection only if… showed no clear difference in locoregional recurrence compared with planned neck dissection before or after chemoradiotherapy (moderate certainty).

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
3 years
HR 1.00 [0.94, 1.06]
1 study · 564 participants
Moderate

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
Adverse events: 22 surgical complications in the PET-CT group vs 83 in the planned-surgery group (Mehanna 2017).
1 study · 564 participants
Very low

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Disease-free survival · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
Disease-free survival: outcome not reported in a usable way (Mehanna 2017: disease-specific and other-cause mortality did not differ, P=0.80 and 0.41).
1 study
GRADE not reported

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Limitation of chewing or swallowing · Adults (>18 years) with established dry socket following permanent tooth extraction

The review found no eligible studies for this question.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
No studies reported this outcome
0 studies
No studies found

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Swelling (mean) · Adults (>18 years) with established dry socket following permanent tooth extraction

The review found no eligible studies for this question.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
No studies reported this outcome
0 studies
No studies found