Findings

What do systematic reviews say?

418 questions · 423 findings · 44 reviews · Eyes and Vision

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No studies found 122 · 28.8%GRADE not reported 26 · 6.1%Very low 98 · 23.2%Low 120 · 28.4%Moderate 53 · 12.5%High 4 · 0.9%

Intervention not reported

Bifocal spectacles vs SVLs with timolol drops · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 97 participants
Moderate

Intervention not reported

Tropicamide plus bifocal spectacles vs SVLs · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
GRADE not reported

Intervention not reported

Adverse effects · children with myopia (nearsightedness)

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Multifocal vs single vision lens spectacles · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1463 participants
Moderate

Intervention not reported

Peripheral plus spectacles vs single vision lens spectacles · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 597 participants
Low

Intervention not reported

Bifocal vs single vision soft contact lenses · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 300 participants
Low

Intervention not reported

Rigid gas permeable contact lenses vs spectacles or soft contact lenses · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 420 participants
Very low

Intervention not reported

Orthokeratology contact lenses vs single vision lenses · children with myopia (nearsightedness)

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Spherical aberration soft contact lenses vs single vision soft contact lenses · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 209 participants
Low

Intervention not reported

Antimuscarinic agents vs placebo · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 629 participants
Moderate

Intervention not reported

Atropine vs tropicamide · children with myopia (nearsightedness)

1 finding from 1 review

Interventions to slow progression of myopia in children 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 196 participants
Low

Combined trabeculotomy with trabeculectomy vs trabeculotomy

Mean intraocular pressure · children at or before five years of age with primary congenital glaucoma

1 finding from 1 review

Surgical interventions for primary congenital glaucoma 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 88 participants
Very low

Combined trabeculotomy with trabeculectomy vs trabeculotomy

Proportion of participants with IOP≤ 21 mmHg, with or without ocular hypotensive medications 1 year · children at or before five years of age with primary congenital glaucoma

It is very uncertain whether combined trabeculotomy with trabeculectomy changes surgical success: proportion with postoperative IOP ≤ 21 mmHg with… compared with trabeculotomy (very low certainty).

1 finding from 1 review

Surgical interventions for primary congenital glaucoma 2020 · Cochrane Headline outcomes only
RR 1.01 [0.9, 1.14]
3 studies · 102 participants
Very low

Combined trabeculotomy with trabeculectomy vs trabeculotomy

Adverse outcomes Up to 3 years · children at or before five years of age with primary congenital glaucoma

It is very uncertain whether combined trabeculotomy with trabeculectomy changes adverse outcomes Up to 3 years compared with trabeculotomy (very low certainty).

1 finding from 1 review

Surgical interventions for primary congenital glaucoma 2020 · Cochrane Headline outcomes only
RR 0.73 [0.1, 5.43]
3 studies · 102 participants
Very low

Viscotrabeculotomy vs conventional trabeculotomy

Mean IOP ( · children at or before five years of age with primary congenital glaucoma

1 finding from 1 review

Surgical interventions for primary congenital glaucoma 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 42 participants
Very low

Viscotrabeculotomy vs conventional trabeculotomy

Proportion with postoperative IOP ≤ 21 mmHg (surgical success) with or without glaucoma medications 6 months after surgery · children at or before five years of age with primary congenital glaucoma

It is very uncertain whether viscotrabeculotomy changes proportion with postoperative IOP ≤ 21 mmHg (surgical success) with… compared with conventional trabeculotomy (very low certainty).

1 finding from 1 review

Surgical interventions for primary congenital glaucoma 2020 · Cochrane Headline outcomes only
RR 1.11 [0.7, 1.78]
1 study · 41 participants
Very low

Viscotrabeculotomy vs conventional trabeculotomy

Hyphema · children at or before five years of age with primary congenital glaucoma

Viscotrabeculotomy showed no clear difference in adverse outcomes—hyphema Up to 6 months after surgery compared with conventional trabeculotomy (low certainty).

1 finding from 1 review

Surgical interventions for primary congenital glaucoma 2020 · Cochrane Headline outcomes only
RR 1.33 [0.63, 2.83]
2 studies · 57 participants
Low

Microcatheter‐assisted trabeculotomy vs conventional trabeculotomy

Mean IOP ( · children at or before five years of age with primary congenital glaucoma

1 finding from 1 review

Surgical interventions for primary congenital glaucoma 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 99 participants
Moderate

Microcatheter‐assisted trabeculotomy vs conventional trabeculotomy

Proportion of participants with IOP≤ 21 mmHg, with or without ocular hypotensive medications 1 year · children at or before five years of age with primary congenital glaucoma

Microcatheter‐assisted trabeculotomy probably leads to higher proportion with postoperative IOP ≤ 21 mmHg (surgical success) with… compared with conventional trabeculotomy (moderate certainty).

1 finding from 1 review

Surgical interventions for primary congenital glaucoma 2020 · Cochrane Headline outcomes only
RR 1.54 [1.2, 1.97]
2 studies · 99 participants
Moderate

Microcatheter‐assisted trabeculotomy vs conventional trabeculotomy

Hyphema · children at or before five years of age with primary congenital glaucoma

Microcatheter‐assisted trabeculotomy probably leads to higher adverse outcomes— hyphema Up to 1 year after surgery compared with conventional trabeculotomy (moderate certainty).

1 finding from 1 review

Surgical interventions for primary congenital glaucoma 2020 · Cochrane Headline outcomes only
RR 2.25 [1.25, 4.04]
2 studies · 102 participants
Moderate