Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Overall survival at 5‐year · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in overall survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Event‐free survival · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in event‐free survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Treatment‐related mortality · women with early poor prognosis breast cancer

High‐dose chemotherapy leads to higher treatment‐related mortality compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Second cancers at 4 ‐ 9‐year median · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in second cancers at 4 ‐ 9‐year median compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐frequency oscillation vs conventional ventilation

Mortality (at 30 days or until hospital discharge) · people with Acute Respiratory Distress Syndrome

It is very uncertain whether high‐frequency oscillation changes mortality (at 30 days or until hospital discharge) compared with conventional ventilation (very low certainty).

1 finding from 1 review

High‐frequency oscillation vs conventional ventilation

Mortality (at 6 months) · people with Acute Respiratory Distress Syndrome

It is very uncertain whether high‐frequency oscillation changes mortality (at 6 months) compared with conventional ventilation (very low certainty).

1 finding from 1 review