Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

572 questions · 579 findings · 55 reviews · Headline outcomes only

No studies found 60 · 10.4%GRADE not reported 42 · 7.3%Very low 205 · 35.4%Low 210 · 36.3%Moderate 52 · 9%High 10 · 1.7%

Fish oil lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

It is very uncertain whether all alternative LE changes retinopathy of prematurity (≥ stage 3) compared with S‐LE (very low certainty).

1 finding from 1 review

Intravenous vs intraosseous route

Insertion failures · adults or children requiring fluid delivered by a parenteral route (one study testing insertion and the volume of fluid delivered in…

Intravenous may leads to higher insertion failures compared with intraosseous route (low certainty).

1 finding from 1 review