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What do systematic reviews say?

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Evidence found and GRADE certainty

339 questions · 346 findings · 42 reviews · Headline outcomes only

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No studies found 74 · 21.4%GRADE not reported 8 · 2.3%Very low 72 · 20.8%Low 107 · 30.9%Moderate 68 · 19.7%High 17 · 4.9%

Flunarizine vs placebo

Recurrence of stroke at the end of · people with acute ischemic stroke

Flunarizine showed no clear difference in recurrence of stroke at the end of compared with placebo (low certainty).

1 finding from 1 review

Flunarizine vs placebo

Adverse events during treatment period · people with acute ischemic stroke

Flunarizine may leads to higher adverse events during treatment period compared with placebo (low certainty).

1 finding from 1 review

Isradipine vs placebo

Death or dependency at end of · people with acute ischemic stroke

Isradipine showed no clear difference in death or dependency at end of compared with placebo (low certainty).

1 finding from 1 review

Isradipine vs placebo

Death at the end of · people with acute ischemic stroke

Isradipine showed no clear difference in death at the end of compared with placebo (low certainty).

1 finding from 1 review

Nimodipine vs placebo

Death or dependency at end of · people with acute ischemic stroke

Nimodipine showed no clear difference in death or dependency at end of compared with placebo (moderate certainty).

1 finding from 1 review

Nimodipine vs placebo

Death at the end of treatment · people with acute ischemic stroke

Nimodipine showed no clear difference in death at the end of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Tardive dyskinesia ‐ not improved to a clinically important extent · people with antipsychotic‐induced tardive dyskinesia

It is very uncertain whether the intervention changes tardive dyskinesia ‐ not improved to a clinically important extent (very low certainty).

1 finding from 1 review

Intervention not reported

Tardive dyskinesia ‐ deterioration · people with antipsychotic‐induced tardive dyskinesia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse effects ‐ important extrapyramidal adverse effects · people with antipsychotic‐induced tardive dyskinesia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Acceptability of treatment ‐ leaving the study early · people with antipsychotic‐induced tardive dyskinesia

The review found no eligible studies for this question.

1 finding from 1 review